4ZOM

RORgamma in complex with inverse agonist 4j.

Summary for 4ZOM

Entry DOI	10.2210/pdb4zom/pdb
Descriptor	Nuclear receptor ROR-gamma, N-{4-[3-(acetylamino)-1-(propan-2-yl)-1H-pyrazol-5-yl]-2-[(1R,5S)-3-azabicyclo[3.1.0]hex-3-yl]phenyl}-2-chloro-6-fluoro-N-methylbenzamide (3 entities in total)
Functional Keywords	rorgamma inverse agonist, transcription
Biological source	Homo sapiens (Human)
Cellular location	Nucleus : P51449
Total number of polymer chains	4
Total formula weight	106680.94
Authors	Marcotte, D.J. (deposition date: 2015-05-06, release date: 2015-06-17, Last modification date: 2023-09-27)
Primary citation	Wang, T.,Banerjee, D.,Bohnert, T.,Chao, J.,Enyedy, I.,Fontenot, J.,Guertin, K.,Jones, H.,Lin, E.Y.,Marcotte, D.,Talreja, T.,Van Vloten, K. Discovery of novel pyrazole-containing benzamides as potent ROR gamma inverse agonists. Bioorg.Med.Chem.Lett., 25:2985-2990, 2015 Cited by PubMed: 26048789 DOI: 10.1016/j.bmcl.2015.05.028 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.27 Å)

Structure validation