3JY9

Janus Kinase 2 Inhibitors

Summary for 3JY9

• Entry DOI: 10.2210/pdb3jy9/pdb
• Descriptor: Tyrosine-protein kinase JAK2, (3S)-3-(4-hydroxyphenyl)-1,5-dihydro-1,5,12-triazabenzo[4,5]cycloocta[1,2,3-cd]inden-4(3H)-one, SODIUM ION, ... (4 entities in total)
• Functional Keywords: kinase, inhibitor, jak2, janus kinase, atp-binding, disease mutation, membrane, nucleotide-binding, phosphoprotein, proto-oncogene, sh2 domain, transferase, tyrosine-protein kinase
• Biological source: Homo sapiens (human)
• Cellular location: Endomembrane system; Peripheral membrane protein (By similarity): O60674
• Total number of polymer chains: 1
• Total formula weight: 37019.03

Authors

Zuccola, H.J.,Ledeboer, M.W.,Pierce, A.C. (deposition date: 2009-09-21, release date: 2009-12-01, Last modification date: 2024-04-03)

• Primary citation: Wang, T.,Duffy, J.P.,Wang, J.,Halas, S.,Salituro, F.G.,Pierce, A.C.,Zuccola, H.J.,Black, J.R.,Hogan, J.K.,Jepson, S.,Shlyakter, D.,Mahajan, S.,Gu, Y.,Hoock, T.,Wood, M.,Furey, B.F.,Frantz, J.D.,Dauffenbach, L.M.,Germann, U.A.,Fan, B.,Namchuk, M.,Bennani, Y.L.,Ledeboer, M.W.; Janus kinase 2 inhibitors. Synthesis and characterization of a novel polycyclic azaindole.; J.Med.Chem., 52:7938-7941, 2009; PubMed: 20014869; DOI: 10.1021/jm901383u

Experimental method

X-RAY DIFFRACTION (2.1 Å)