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7ETW

Cryo-EM structure of Scap/Insig complex in the present of digitonin.

Summary for 7ETW
Entry DOI10.2210/pdb7etw/pdb
EMDB information31303
DescriptorInsulin-induced gene 2 protein, Sterol regulatory element-binding protein cleavage-activating protein, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (4 entities in total)
Functional Keywordssterol sensing, srebp, scap, insig, cholestrol, digitonin, membrane protein
Biological sourceHomo sapiens (Human)
More
Total number of polymer chains2
Total formula weight111954.84
Authors
Yan, R.,Cao, P.,Song, W.,Li, Y.,Wang, T.,Qian, H.,Yan, C.,Yan, N. (deposition date: 2021-05-14, release date: 2021-06-23, Last modification date: 2024-10-23)
Primary citationYan, R.,Cao, P.,Song, W.,Li, Y.,Wang, T.,Qian, H.,Yan, C.,Yan, N.
Structural basis for sterol sensing by Scap and Insig
Cell Rep, 35:109299-, 2021
Cited by
DOI: 10.1016/j.celrep.2021.109299
PDB entries with the same primary citation
Experimental method
ELECTRON MICROSCOPY (4.1 Å)
Structure validation

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