7ETW

Cryo-EM structure of Scap/Insig complex in the present of digitonin.

Summary for 7ETW

• Entry DOI: 10.2210/pdb7etw/pdb
• EMDB information: 31303
• Descriptor: Insulin-induced gene 2 protein, Sterol regulatory element-binding protein cleavage-activating protein, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (4 entities in total)
• Functional Keywords: sterol sensing, srebp, scap, insig, cholestrol, digitonin, membrane protein
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 2
• Total formula weight: 111954.84

Authors

Yan, R.,Cao, P.,Song, W.,Li, Y.,Wang, T.,Qian, H.,Yan, C.,Yan, N. (deposition date: 2021-05-14, release date: 2021-06-23, Last modification date: 2022-03-02)

• Primary citation: Yan, R.,Cao, P.,Song, W.,Li, Y.,Wang, T.,Qian, H.,Yan, C.,Yan, N.; Structural basis for sterol sensing by Scap and Insig; Cell Rep, 35:109299-, 2021; DOI: 10.1016/j.celrep.2021.109299

Experimental method

ELECTRON MICROSCOPY (4.1 Å)