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7ETW

Cryo-EM structure of Scap/Insig complex in the present of digitonin.

Functional Information from GO Data
ChainGOidnamespacecontents
A0005515molecular_functionprotein binding
A0005783cellular_componentendoplasmic reticulum
A0005789cellular_componentendoplasmic reticulum membrane
A0006641biological_processtriglyceride metabolic process
A0006695biological_processcholesterol biosynthetic process
A0006991biological_processresponse to sterol depletion
A0008142molecular_functionoxysterol binding
A0008203biological_processcholesterol metabolic process
A0008289molecular_functionlipid binding
A0010894biological_processnegative regulation of steroid biosynthetic process
A0016020cellular_componentmembrane
A0016126biological_processsterol biosynthetic process
A0032869biological_processcellular response to insulin stimulus
A0032933biological_processSREBP signaling pathway
A0032937cellular_componentSREBP-SCAP-Insig complex
A0036316biological_processSREBP-SCAP complex retention in endoplasmic reticulum
A0042472biological_processinner ear morphogenesis
A0042474biological_processmiddle ear morphogenesis
A0045717biological_processnegative regulation of fatty acid biosynthetic process
A0060021biological_processroof of mouth development
A0060363biological_processcranial suture morphogenesis
A0140311molecular_functionprotein sequestering activity
B0000139cellular_componentGolgi membrane
B0005789cellular_componentendoplasmic reticulum membrane
B0032933biological_processSREBP signaling pathway
B0032934molecular_functionsterol binding
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues136
DetailsTOPO_DOM: Cytoplasmic => ECO:0000250|UniProtKB:P97260
ChainResidueDetails
BMET1-HIS18
BPHE301-LYS312
BLYS366-GLY401
BARG445-ARG518

site_idSWS_FT_FI2
Number of Residues20
DetailsTRANSMEM: Helical; Name=1 => ECO:0000255
ChainResidueDetails
BGLY19-ALA39

site_idSWS_FT_FI3
Number of Residues419
DetailsTOPO_DOM: Lumenal => ECO:0000250|UniProtKB:P97260
ChainResidueDetails
BCYS40-GLU279
BCYS334-ASN344
BVAL423
BARG540-TYR709

site_idSWS_FT_FI4
Number of Residues20
DetailsTRANSMEM: Helical; Name=2 => ECO:0000255
ChainResidueDetails
BILE280-TYR300

site_idSWS_FT_FI5
Number of Residues20
DetailsTRANSMEM: Helical; Name=3 => ECO:0000255
ChainResidueDetails
BTRP313-LEU333

site_idSWS_FT_FI6
Number of Residues20
DetailsTRANSMEM: Helical; Name=4 => ECO:0000255
ChainResidueDetails
BGLY345-THR365

site_idSWS_FT_FI7
Number of Residues20
DetailsTRANSMEM: Helical; Name=5 => ECO:0000255
ChainResidueDetails
BILE402-VAL422

site_idSWS_FT_FI8
Number of Residues20
DetailsTRANSMEM: Helical; Name=6 => ECO:0000255
ChainResidueDetails
BGLY424-ILE444

site_idSWS_FT_FI9
Number of Residues20
DetailsTRANSMEM: Helical; Name=7 => ECO:0000255
ChainResidueDetails
BLEU519-LEU539

site_idSWS_FT_FI10
Number of Residues20
DetailsTRANSMEM: Helical; Name=8 => ECO:0000255
ChainResidueDetails
BLYS710-TYR730

site_idSWS_FT_FI11
Number of Residues3
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
BASN263
BASN590
BASN641

site_idSWS_FT_FI12
Number of Residues3
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:Q6GQT6
ChainResidueDetails
BLYS454
BLYS466

226707

PDB entries from 2024-10-30

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