7ETW
Cryo-EM structure of Scap/Insig complex in the present of digitonin.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Insulin-induced gene 2 protein | polymer | 225 | 24749.7 | 1 | UniProt (Q9Y5U4) Pfam (PF07281) | Homo sapiens (Human) | INSIG-2 |
| 2 | B (B) | Sterol regulatory element-binding protein cleavage-activating protein | polymer | 735 | 81863.5 | 1 | UniProt (Q12770) Pfam (PF12349) | Homo sapiens (Human) | SCAP,SREBP cleavage-activating protein |
| 3 | C (D) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 1 | In PDB GlyTouCan (G42666HT) | |||
| 4 | D, E, F, G (A) | Digitonin | non-polymer | 1229.3 | 4 | Chemie (AJP) |
Sequence modifications
A: 1 - 225 (UniProt: Q9Y5U4)
| PDB | External Database | Details |
|---|---|---|
| Ser 14 | Cys 14 | engineered mutation |
| Ser 90 | Cys 90 | engineered mutation |
| Ser 215 | Cys 215 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 106613.2 | |
| Branched | Number of molecules | 1 |
| Total formula weight | 424.4 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 4917.2 | |
| All* | Total formula weight | 111954.8 |
