8V7Z

Phosphorylated, ATP-bound, E1371Q human cystic fibrosis transmembrane conductance regulator (E1371Q-CFTR)

Summary for 8V7Z

• Entry DOI: 10.2210/pdb8v7z/pdb
• Related: 8V81
• EMDB information: 43011 43014
• Descriptor: Cystic fibrosis transmembrane conductance regulator, MAGNESIUM ION, ADENOSINE-5'-TRIPHOSPHATE, ... (5 entities in total)
• Functional Keywords: cystic fibrosis, chloride channel, hydrolysis-deficient mutant, membrane protein
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 166768.90

Authors

Gao, X.,Hwang, T. (deposition date: 2023-12-04, release date: 2024-07-17)

• Primary citation: Gao, X.,Yeh, H.,Yang, Z.,Fan, C.,Jiang, F.,Howard, R.J.,Lindahl, E.,Kappes, J.C.,Hwang, T.; Allosteric inhibition of CFTR gating by CFTRinh-172 binding in the pore; Nat Commun, 2024

Experimental method

ELECTRON MICROSCOPY (3.4 Å)