8V7Z
Phosphorylated, ATP-bound, E1371Q human cystic fibrosis transmembrane conductance regulator (E1371Q-CFTR)
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Cystic fibrosis transmembrane conductance regulator | polymer | 1421 | 161518.9 | 1 | UniProt (P13569) Pfam (PF00664) Pfam (PF00005) Pfam (PF14396) In PDB | Homo sapiens (human) | CFTR,ATP-binding cassette sub-family C member 7,Channel conductance-controlling ATPase,cAMP-dependent chloride channel |
2 | A | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
3 | A | ADENOSINE-5'-TRIPHOSPHATE | non-polymer | 507.2 | 2 | Chemie (ATP) | |||
4 | A | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate | non-polymer | 760.1 | 5 | Chemie (POV) | |||
5 | A | CHOLESTEROL | non-polymer | 386.7 | 1 | Chemie (CLR) |
Sequence modifications
A: 11 - 1431 (UniProt: P13569)
PDB | External Database | Details |
---|---|---|
Pro 492 | Ser 492 | conflict |
Pro 495 | Ser 495 | conflict |
Pro 534 | Ala 534 | conflict |
Thr 539 | Ile 539 | conflict |
Lys 555 | Arg 555 | conflict |
Gln 1371 | Glu 1371 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 161518.9 | |
Non-Polymers* | Number of molecules | 10 |
Total formula weight | 5250.0 | |
All* | Total formula weight | 166768.9 |