7EGQ
Co-transcriptional capping machineries in SARS-CoV-2 RTC: Coupling of N7-methyltransferase and 3'-5' exoribonuclease with polymerase reveals mechanisms for capping and proofreading
Summary for 7EGQ
Entry DOI | 10.2210/pdb7egq/pdb |
EMDB information | 31138 |
Descriptor | RNA-directed RNA polymerase, ZINC ION, MAGNESIUM ION, ... (11 entities in total) |
Functional Keywords | sars-cov-2, replication-transcription complex, nsp10 and nsp14, viral protein-rna complex, viral protein/rna |
Biological source | Severe acute respiratory syndrome coronavirus 2 (2019-nCoV) More |
Total number of polymer chains | 22 |
Total formula weight | 801369.78 |
Authors | Yan, L.M.,Yang, Y.X.,Li, M.Y.,Zhang, Y.,Zheng, L.T.,Ge, J.,Huang, Y.C.,Liu, Z.Y.,Wang, T.,Gao, S.,Zhang, R.,Huang, Y.Y.,Guddat, L.W.,Gao, Y.,Rao, Z.H.,Lou, Z.Y. (deposition date: 2021-03-25, release date: 2021-07-21) |
Primary citation | Yan, L.,Yang, Y.,Li, M.,Zhang, Y.,Zheng, L.,Ge, J.,Huang, Y.C.,Liu, Z.,Wang, T.,Gao, S.,Zhang, R.,Huang, Y.Y.,Guddat, L.W.,Gao, Y.,Rao, Z.,Lou, Z. Coupling of N7-methyltransferase and 3'-5' exoribonuclease with SARS-CoV-2 polymerase reveals mechanisms for capping and proofreading. Cell, 184:3474-3485.e11, 2021 Cited by PubMed: 34143953DOI: 10.1016/j.cell.2021.05.033 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.35 Å) |
Structure validation
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