7EGQ

Co-transcriptional capping machineries in SARS-CoV-2 RTC: Coupling of N7-methyltransferase and 3'-5' exoribonuclease with polymerase reveals mechanisms for capping and proofreading

Summary for 7EGQ

• Entry DOI: 10.2210/pdb7egq/pdb
• EMDB information: 31138
• Descriptor: RNA-directed RNA polymerase, ZINC ION, MAGNESIUM ION, ... (11 entities in total)
• Functional Keywords: sars-cov-2, replication-transcription complex, nsp10 and nsp14, viral protein-rna complex, viral protein/rna
• Biological source: Severe acute respiratory syndrome coronavirus 2 (2019-nCoV); More
• Total number of polymer chains: 22
• Total formula weight: 801369.78

Authors

Yan, L.M.,Yang, Y.X.,Li, M.Y.,Zhang, Y.,Zheng, L.T.,Ge, J.,Huang, Y.C.,Liu, Z.Y.,Wang, T.,Gao, S.,Zhang, R.,Huang, Y.Y.,Guddat, L.W.,Gao, Y.,Rao, Z.H.,Lou, Z.Y. (deposition date: 2021-03-25, release date: 2021-07-21, Last modification date: 2024-06-05)

• Primary citation: Yan, L.,Yang, Y.,Li, M.,Zhang, Y.,Zheng, L.,Ge, J.,Huang, Y.C.,Liu, Z.,Wang, T.,Gao, S.,Zhang, R.,Huang, Y.Y.,Guddat, L.W.,Gao, Y.,Rao, Z.,Lou, Z.; Coupling of N7-methyltransferase and 3'-5' exoribonuclease with SARS-CoV-2 polymerase reveals mechanisms for capping and proofreading.; Cell, 184:3474-3485.e11, 2021; PubMed: 34143953; DOI: 10.1016/j.cell.2021.05.033

Experimental method

ELECTRON MICROSCOPY (3.35 Å)