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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

7EGQ

Co-transcriptional capping machineries in SARS-CoV-2 RTC: Coupling of N7-methyltransferase and 3'-5' exoribonuclease with polymerase reveals mechanisms for capping and proofreading

Functional Information from GO Data
ChainGOidnamespacecontents
A0003723molecular_functionRNA binding
A0003968molecular_functionRNA-directed RNA polymerase activity
A0005524molecular_functionATP binding
A0006351biological_processDNA-templated transcription
A0039694biological_processviral RNA genome replication
B0004197molecular_functioncysteine-type endopeptidase activity
B0008242molecular_functionomega peptidase activity
B0016740molecular_functiontransferase activity
C0004197molecular_functioncysteine-type endopeptidase activity
C0008242molecular_functionomega peptidase activity
C0016740molecular_functiontransferase activity
D0004197molecular_functioncysteine-type endopeptidase activity
D0008242molecular_functionomega peptidase activity
D0016740molecular_functiontransferase activity
E0004386molecular_functionhelicase activity
E0005524molecular_functionATP binding
E0008270molecular_functionzinc ion binding
F0004386molecular_functionhelicase activity
F0005524molecular_functionATP binding
F0008270molecular_functionzinc ion binding
G0003723molecular_functionRNA binding
G0019079biological_processviral genome replication
H0003723molecular_functionRNA binding
H0008270molecular_functionzinc ion binding
H0019079biological_processviral genome replication
K0000175molecular_function3'-5'-RNA exonuclease activity
K0004482molecular_functionmRNA 5'-cap (guanine-N7-)-methyltransferase activity
K0004532molecular_functionRNA exonuclease activity
K0008168molecular_functionmethyltransferase activity
N0003723molecular_functionRNA binding
N0003968molecular_functionRNA-directed RNA polymerase activity
N0005524molecular_functionATP binding
N0006351biological_processDNA-templated transcription
N0039694biological_processviral RNA genome replication
O0004197molecular_functioncysteine-type endopeptidase activity
O0008242molecular_functionomega peptidase activity
O0016740molecular_functiontransferase activity
P0004197molecular_functioncysteine-type endopeptidase activity
P0008242molecular_functionomega peptidase activity
P0016740molecular_functiontransferase activity
Q0004197molecular_functioncysteine-type endopeptidase activity
Q0008242molecular_functionomega peptidase activity
Q0016740molecular_functiontransferase activity
R0004386molecular_functionhelicase activity
R0005524molecular_functionATP binding
R0008270molecular_functionzinc ion binding
S0004386molecular_functionhelicase activity
S0005524molecular_functionATP binding
S0008270molecular_functionzinc ion binding
T0003723molecular_functionRNA binding
T0019079biological_processviral genome replication
U0003723molecular_functionRNA binding
U0008270molecular_functionzinc ion binding
U0019079biological_processviral genome replication
X0000175molecular_function3'-5'-RNA exonuclease activity
X0004482molecular_functionmRNA 5'-cap (guanine-N7-)-methyltransferase activity
X0004532molecular_functionRNA exonuclease activity
X0008168molecular_functionmethyltransferase activity
Functional Information from PROSITE/UniProt
site_idPS00213
Number of Residues12
DetailsLIPOCALIN Lipocalin signature. GTS..KFYGGWHNM
ChainResidueDetails
AGLY590-MET601
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues508
DetailsDomain: {"description":"NiRAN","evidences":[{"source":"PROSITE-ProRule","id":"PRU01292","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues50
DetailsRepeat: {"description":"LRR 7","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues196
DetailsDomain: {"description":"Nsp12 Interface","evidences":[{"source":"PROSITE-ProRule","id":"PRU01344","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues324
DetailsDomain: {"description":"RdRp catalytic","evidences":[{"source":"PROSITE-ProRule","id":"PRU00539","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues428
DetailsRegion: {"description":"RdRp Fingers N-ter","evidences":[{"source":"PROSITE-ProRule","id":"PRU01293","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues20
DetailsRegion: {"description":"Interaction with RMP Remdesivir","evidences":[{"source":"PubMed","id":"32358203","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues76
DetailsRegion: {"description":"RdRp Palm N-ter","evidences":[{"source":"PROSITE-ProRule","id":"PRU01293","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues116
DetailsRegion: {"description":"RdRp Fingers C-ter","evidences":[{"source":"PROSITE-ProRule","id":"PRU01293","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues270
DetailsRegion: {"description":"RdRp Palm C-ter","evidences":[{"source":"PROSITE-ProRule","id":"PRU01293","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues6
DetailsActive site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU01293","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues4
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"33232691","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7CYQ","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues8
DetailsBinding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU01344","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"32358203","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32526208","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33232691","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7CYQ","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues6
DetailsBinding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU01293","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"32358203","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32526208","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33232691","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7CYQ","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI14
Number of Residues2
DetailsBinding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU01293","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"32358203","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32526208","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"33232691","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI15
Number of Residues108
DetailsRepeat: {"description":"LRR 6","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI16
Number of Residues80
DetailsRepeat: {"description":"LRR 8","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI17
Number of Residues48
DetailsBinding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00986","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"33232691","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7CYQ","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI18
Number of Residues28
DetailsBinding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00990","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI19
Number of Residues224
DetailsDomain: {"description":"CV ZBD","evidences":[{"source":"PROSITE-ProRule","id":"PRU00986","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI20
Number of Residues362
DetailsDomain: {"description":"(+)RNA virus helicase ATP-binding","evidences":[{"source":"PROSITE-ProRule","id":"PRU00990","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI21
Number of Residues224
DetailsDomain: {"description":"Nsp9 ssRNA-binding","evidences":[{"source":"PROSITE-ProRule","id":"PRU01296","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI22
Number of Residues16
DetailsBinding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU01297","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI23
Number of Residues430
DetailsDomain: {"description":"ExoN","evidences":[{"source":"PROSITE-ProRule","id":"PRU01298","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI24
Number of Residues28
DetailsRegion: {"description":"GpppA-binding","evidences":[{"source":"PROSITE-ProRule","id":"PRU01299","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI25
Number of Residues10
DetailsActive site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU01298","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI26
Number of Residues34
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"36546776","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI27
Number of Residues12
DetailsBinding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU01299","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

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PDB entries from 2026-03-18

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