4ZUV
| Crystal structure of Equine MHC I(Eqca-N*00602) in complexed with equine infectious anaemia virus (EIAV) derived peptide Env-RW12 | 分子名称: | ARG-VAL-GLU-ASP-VAL-THR-ASN-THR-ALA-GLU-TYR-TRP, Beta-2-microglobulin, Classical MHC class I antigen | 著者 | Yao, S, Liu, J, Qi, J, Chen, R, Zhang, N, Liu, Y, Xia, C. | 登録日 | 2015-05-17 | 公開日 | 2016-04-06 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Structural Illumination of Equine MHC Class I Molecules Highlights Unconventional Epitope Presentation Manner That Is Evolved in Equine Leukocyte Antigen Alleles J Immunol., 196, 2016
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6KC7
| Crystal structure of Nme1Cas9 in complex with sgRNA and target DNA (ATATGATT PAM) in seed-base paring state | 分子名称: | CRISPR-associated endonuclease Cas9, DNA (5'-D(*AP*TP*AP*TP*GP*AP*TP*TP*TP*TP*A)-3'), DNA (5'-D(*TP*AP*AP*AP*AP*TP*CP*AP*TP*AP*TP*GP*TP*AP*AP*AP*GP*TP*T)-3'), ... | 著者 | Sun, W, Yang, J, Cheng, Z, Liu, C, Wang, K, Huang, X, Wang, Y. | 登録日 | 2019-06-27 | 公開日 | 2019-11-06 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | 主引用文献 | Structures of Neisseria meningitidis Cas9 Complexes in Catalytically Poised and Anti-CRISPR-Inhibited States. Mol.Cell, 76, 2019
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6KE1
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2EA2
| h-MetAP2 complexed with A773812 | 分子名称: | 3-ETHYL-6-{[(4-FLUOROPHENYL)SULFONYL]AMINO}-2-METHYLBENZOIC ACID, MANGANESE (II) ION, Methionine aminopeptidase 2 | 著者 | Park, C.H. | 登録日 | 2007-01-30 | 公開日 | 2008-02-05 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Lead optimization of methionine aminopeptidase-2 (MetAP2) inhibitors containing sulfonamides of 5,6-disubstituted anthranilic acids Bioorg.Med.Chem.Lett., 17, 2007
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2EA4
| h-MetAP2 complexed with A797859 | 分子名称: | 2-(2-AMINOETHOXY)-3-ETHYL-6-{[(4-FLUOROPHENYL)SULFONYL]AMINO}BENZOIC ACID, MANGANESE (II) ION, Methionine aminopeptidase 2 | 著者 | Park, C.H. | 登録日 | 2007-01-30 | 公開日 | 2008-02-05 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | 主引用文献 | Lead optimization of methionine aminopeptidase-2 (MetAP2) inhibitors containing sulfonamides of 5,6-disubstituted anthranilic acids Bioorg.Med.Chem.Lett., 17, 2007
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6XBW
| Cryo-EM structure of V-ATPase from bovine brain, state 1 | 分子名称: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 2-acetamido-2-deoxy-beta-D-glucopyranose, ADENOSINE-5'-DIPHOSPHATE, ... | 著者 | Wang, R, Li, X. | 登録日 | 2020-06-07 | 公開日 | 2020-08-19 | 実験手法 | ELECTRON MICROSCOPY (3.37 Å) | 主引用文献 | Cryo-EM structures of intact V-ATPase from bovine brain. Nat Commun, 11, 2020
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6XBY
| Cryo-EM structure of V-ATPase from bovine brain, state 2 | 分子名称: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 2-acetamido-2-deoxy-beta-D-glucopyranose, ADENOSINE-5'-DIPHOSPHATE, ... | 著者 | Wang, R, Li, X. | 登録日 | 2020-06-07 | 公開日 | 2020-08-19 | 実験手法 | ELECTRON MICROSCOPY (3.79 Å) | 主引用文献 | Cryo-EM structures of intact V-ATPase from bovine brain. Nat Commun, 11, 2020
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6XNU
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8HJ4
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8HFS
| The structure of LcnA, LciA, and the man-PTS of Lactococcus lactis | 分子名称: | Bacteriocin lactococcin-A, Lactococcin-A immunity protein, Mannose-specific PTS system, ... | 著者 | Wang, J.W. | 登録日 | 2022-11-12 | 公開日 | 2023-02-08 | 最終更新日 | 2024-07-17 | 実験手法 | ELECTRON MICROSCOPY (2.98 Å) | 主引用文献 | Structural Basis of the Mechanisms of Action and Immunity of Lactococcin A, a Class IId Bacteriocin. Appl.Environ.Microbiol., 89, 2023
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7VUZ
| Cryo-EM structure of pseudoallergen receptor MRGPRX2 complex with PAMP-12, state2 | 分子名称: | CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Li, Y, Yang, F. | 登録日 | 2021-11-04 | 公開日 | 2021-12-01 | 最終更新日 | 2022-07-20 | 実験手法 | ELECTRON MICROSCOPY (2.89 Å) | 主引用文献 | Structure, function and pharmacology of human itch receptor complexes. Nature, 600, 2021
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7VV4
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7VDM
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7VV5
| Cryo-EM structure of pseudoallergen receptor MRGPRX2 complex with C48/80, state1 | 分子名称: | 2-[4-methoxy-3-[[2-methoxy-3-[[2-methoxy-5-[2-(methylamino)ethyl]phenyl]methyl]-5-[2-(methylamino)ethyl]phenyl]methyl]phenyl]-~{N}-methyl-ethanamine, CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Li, Y, Yang, F. | 登録日 | 2021-11-04 | 公開日 | 2021-12-01 | 最終更新日 | 2022-07-20 | 実験手法 | ELECTRON MICROSCOPY (2.76 Å) | 主引用文献 | Structure, function and pharmacology of human itch receptor complexes. Nature, 600, 2021
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7VDL
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7VDH
| Cryo-EM structure of pseudoallergen receptor MRGPRX2 complex with C48/80, state2 | 分子名称: | 2-[4-methoxy-3-[[2-methoxy-3-[[2-methoxy-5-[2-(methylamino)ethyl]phenyl]methyl]-5-[2-(methylamino)ethyl]phenyl]methyl]phenyl]-~{N}-methyl-ethanamine, CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Li, Y, Yang, F. | 登録日 | 2021-09-07 | 公開日 | 2021-12-01 | 最終更新日 | 2022-07-20 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Structure, function and pharmacology of human itch receptor complexes. Nature, 600, 2021
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7VV0
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7VV6
| Cryo-EM structure of pseudoallergen receptor MRGPRX2 complex with C48/80 (local) | 分子名称: | 2-[4-methoxy-3-[[2-methoxy-3-[[2-methoxy-5-[2-(methylamino)ethyl]phenyl]methyl]-5-[2-(methylamino)ethyl]phenyl]methyl]phenyl]-~{N}-methyl-ethanamine, CHOLESTEROL, Mas-related G-protein coupled receptor member X2 | 著者 | Li, Y, Yang, F. | 登録日 | 2021-11-04 | 公開日 | 2021-12-01 | 最終更新日 | 2022-07-20 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Structure, function and pharmacology of human itch receptor complexes. Nature, 600, 2021
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7VUY
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7VV3
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1YW7
| h-MetAP2 complexed with A444148 | 分子名称: | 5-METHYL-2-[(PHENYLSULFONYL)AMINO]BENZOIC ACID, MANGANESE (II) ION, Methionine aminopeptidase 2 | 著者 | Park, C.H. | 登録日 | 2005-02-17 | 公開日 | 2006-02-21 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Discovery and optimization of anthranilic acid sulfonamides as inhibitors of methionine aminopeptidase-2: a structural basis for the reduction of albumin binding. J.Med.Chem., 49, 2006
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5FBO
| BTK-inhibitor co-structure | 分子名称: | 4-[8-azanyl-3-[(2~{S})-1-[4-(dimethylamino)butanoyl]pyrrolidin-2-yl]imidazo[1,5-a]pyrazin-1-yl]-~{N}-(1,3-thiazol-2-yl)benzamide, 4-[8-azanyl-3-[(3~{R},6~{S})-1-cyclopropylcarbonyl-6-methyl-piperidin-3-yl]imidazo[1,5-a]pyrazin-1-yl]-3-fluoranyl-~{N}-[4-(trifluoromethyl)pyridin-2-yl]benzamide, Tyrosine-protein kinase BTK | 著者 | Fischmann, T.O. | 登録日 | 2015-12-14 | 公開日 | 2016-03-23 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (1.894 Å) | 主引用文献 | Discovery of 8-Amino-imidazo[1,5-a]pyrazines as Reversible BTK Inhibitors for the Treatment of Rheumatoid Arthritis. ACS Med Chem Lett, 7, 2016
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5FBN
| BTK kinase domain with inhibitor 1 | 分子名称: | 1,2-ETHANEDIOL, 4-[8-azanyl-3-[(2~{S})-1-[4-(dimethylamino)butanoyl]pyrrolidin-2-yl]imidazo[1,5-a]pyrazin-1-yl]-~{N}-(1,3-thiazol-2-yl)benzamide, 4-[8-azanyl-3-[(3~{R})-1-(3-methyloxetan-3-yl)carbonylpiperidin-3-yl]imidazo[1,5-a]pyrazin-1-yl]-~{N}-[4-(trifluoromethyl)pyridin-2-yl]benzamide, ... | 著者 | Raaijmakers, H.C.A, Vu-Pham, D. | 登録日 | 2015-12-14 | 公開日 | 2016-02-03 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Discovery of 8-Amino-imidazo[1,5-a]pyrazines as Reversible BTK Inhibitors for the Treatment of Rheumatoid Arthritis. Acs Med.Chem.Lett., 7, 2016
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4ZUS
| Crystal structure of Equine MHC I(Eqca-N*00602) in complexed with equine infectious anaemia virus (EIAV) derived peptide REV-QW11 | 分子名称: | Beta-2-microglobulin, Classical MHC class I antigen, GLN-ALA-GLU-VAL-LEU-GLN-GLU-ARG-LEU-GLU-TRP | 著者 | Yao, S, Liu, J, Qi, J, Chen, R, Zhang, N, Liu, Y, Xia, C. | 登録日 | 2015-05-17 | 公開日 | 2016-04-06 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Structural Illumination of Equine MHC Class I Molecules Highlights Unconventional Epitope Presentation Manner That Is Evolved in Equine Leukocyte Antigen Alleles J Immunol., 196, 2016
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4ZUW
| Crystal structure of Equine MHC I(Eqca-N*00601) in complexed with equine infectious anaemia virus (EIAV) derived peptide Gag-GW12 | 分子名称: | Beta-2-microglobulin, Classical MHC class I antigen, GLY-SER-GLN-LYS-LEU-THR-THR-GLY-ASN-CYS-ASN-TRP | 著者 | Yao, S, Liu, J, Qi, J, Chen, R, Zhang, N, Liu, Y, Xia, C. | 登録日 | 2015-05-17 | 公開日 | 2016-04-06 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Structural Illumination of Equine MHC Class I Molecules Highlights Unconventional Epitope Presentation Manner That Is Evolved in Equine Leukocyte Antigen Alleles J Immunol., 196, 2016
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