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5FBN

BTK kinase domain with inhibitor 1

Summary for 5FBN
Entry DOI10.2210/pdb5fbn/pdb
DescriptorTyrosine-protein kinase BTK, 4-[8-azanyl-3-[(3~{R})-1-(3-methyloxetan-3-yl)carbonylpiperidin-3-yl]imidazo[1,5-a]pyrazin-1-yl]-~{N}-[4-(trifluoromethyl)pyridin-2-yl]benzamide, 4-[8-azanyl-3-[(2~{S})-1-[4-(dimethylamino)butanoyl]pyrrolidin-2-yl]imidazo[1,5-a]pyrazin-1-yl]-~{N}-(1,3-thiazol-2-yl)benzamide, ... (6 entities in total)
Functional Keywordskinase, phosphatase, transferase-transferase inhibitor complex, transferase
Biological sourceHomo sapiens (Human)
Total number of polymer chains2
Total formula weight66563.23
Authors
Raaijmakers, H.C.A.,Vu-Pham, D. (deposition date: 2015-12-14, release date: 2016-02-03, Last modification date: 2019-04-24)
Primary citationLiu, J.,Guiadeen, D.,Krikorian, A.,Gao, X.,Wang, J.,Boga, S.B.,Alhassan, A.B.,Yu, Y.,Vaccaro, H.,Liu, S.,Yang, C.,Wu, H.,Cooper, A.,de Man, J.,Kaptein, A.,Maloney, K.,Hornak, V.,Gao, Y.D.,Fischmann, T.O.,Raaijmakers, H.,Vu-Pham, D.,Presland, J.,Mansueto, M.,Xu, Z.,Leccese, E.,Zhang-Hoover, J.,Knemeyer, I.,Garlisi, C.G.,Bays, N.,Stivers, P.,Brandish, P.E.,Hicks, A.,Kim, R.,Kozlowski, J.A.
Discovery of 8-Amino-imidazo[1,5-a]pyrazines as Reversible BTK Inhibitors for the Treatment of Rheumatoid Arthritis.
Acs Med.Chem.Lett., 7:198-203, 2016
Cited by
PubMed: 26985298
DOI: 10.1021/acsmedchemlett.5b00463
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.8 Å)
Structure validation

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