5FBN

BTK kinase domain with inhibitor 1

Functional Information from GO Data

Chain	GOid	namespace	contents
C	0004672	molecular_function	protein kinase activity
C	0004713	molecular_function	protein tyrosine kinase activity
C	0005524	molecular_function	ATP binding
C	0006468	biological_process	protein phosphorylation
D	0004672	molecular_function	protein kinase activity
D	0004713	molecular_function	protein tyrosine kinase activity
D	0005524	molecular_function	ATP binding
D	0006468	biological_process	protein phosphorylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	20
Details	binding site for residue 5WF C 701

Chain	Residue
C	LEU408
C	GLU475
C	MET477
C	GLY480
C	CYS481
C	ASN484
C	SER538
C	ASP539
C	PHE540
C	LEU542
C	HOH907
C	ALA428
C	HOH918
C	LYS430
C	PHE442
C	MET449
C	MET450
C	LEU460
C	ILE472
C	THR474

---

site_id	AC2
Number of Residues	10
Details	binding site for residue 5WE C 702

Chain	Residue
C	TRP421
C	TYR425
C	SER453
C	TYR461
C	HOH817
C	HOH873
C	HOH906
C	HOH927
C	HOH946
D	5WE703

---

site_id	AC3
Number of Residues	4
Details	binding site for residue CL C 703

Chain	Residue
C	GLU407
C	GLY409
C	VAL416
C	LYS417

---

site_id	AC4
Number of Residues	3
Details	binding site for residue CL D 701

Chain	Residue
D	ARG618
D	5WE704
D	5WE705

---

site_id	AC5
Number of Residues	20
Details	binding site for residue 5WF D 702

Chain	Residue
D	LEU408
D	VAL416
D	ALA428
D	LYS430
D	PHE442
D	MET449
D	LEU460
D	ILE472
D	THR474
D	GLU475
D	MET477
D	GLY480
D	CYS481
D	ASN484
D	SER538
D	ASP539
D	PHE540
D	LEU542
D	HOH888
D	HOH909

---

site_id	AC6
Number of Residues	9
Details	binding site for residue 5WE D 703

Chain	Residue
C	5WE702
D	TRP421
D	TYR425
D	SER453
D	GLN459
D	TYR461
D	HOH808
D	HOH839
D	HOH915

---

site_id	AC7
Number of Residues	5
Details	binding site for residue 5WE D 704

Chain	Residue
D	GLU624
D	CL701
D	5WE705
D	HOH857
D	HOH903

---

site_id	AC8
Number of Residues	11
Details	binding site for residue 5WE D 705

Chain	Residue
D	ARG618
D	GLU624
D	TYR627
D	THR628
D	TYR631
D	CL701
D	5WE704
D	HOH901
D	HOH903
D	HOH949
D	HOH953

---

site_id	AC9
Number of Residues	3
Details	binding site for residue EDO D 706

Chain	Residue
D	THR403
D	PHE404
D	HOH978

---

Functional Information from PROSITE/UniProt

site_id	PS00107
Number of Residues	23
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGTGQFGVVKyGkwrgqyd...........VAIK

Chain	Residue	Details
C	LEU408-LYS430

---

site_id	PS00109
Number of Residues	13
Details	PROTEIN_KINASE_TYR Tyrosine protein kinases specific active-site signature. FLHrDLAARNCLV

Chain	Residue	Details
C	PHE517-VAL529

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10028

Chain	Residue	Details
C	ASP521
D	ASP521

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159

Chain	Residue	Details
C	LEU408
C	LYS430
D	LEU408
D	LYS430

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269|PubMed:20052711, ECO:0007744|PDB:3K54, ECO:0007744|PDB:3OCT

Chain	Residue	Details
C	THR474
D	THR474

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269|PubMed:21280133, ECO:0007744|PDB:3PIY

Chain	Residue	Details
C	LEU542
D	LEU542

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	MOD_RES: Phosphotyrosine; by LYN and SYK => ECO:0000269|PubMed:8630736, ECO:0000269|PubMed:9012831

Chain	Residue	Details
C	TYR551
D	TYR551

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163

Chain	Residue	Details
C	SER604
D	SER604

---

site_id	SWS_FT_FI7
Number of Residues	2
Details	MOD_RES: Phosphotyrosine => ECO:0000269|PubMed:15375214

Chain	Residue	Details
C	TYR617
D	TYR617

---

site_id	SWS_FT_FI8
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0000269|PubMed:15375214

Chain	Residue	Details
C	SER623
D	SER623

---

site_id	SWS_FT_FI9
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:19369195

Chain	Residue	Details
C	SER659
D	SER659

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