5FBN
BTK kinase domain with inhibitor 1
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| C | 0004672 | molecular_function | protein kinase activity |
| C | 0004713 | molecular_function | protein tyrosine kinase activity |
| C | 0005524 | molecular_function | ATP binding |
| C | 0006468 | biological_process | protein phosphorylation |
| D | 0004672 | molecular_function | protein kinase activity |
| D | 0004713 | molecular_function | protein tyrosine kinase activity |
| D | 0005524 | molecular_function | ATP binding |
| D | 0006468 | biological_process | protein phosphorylation |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 20 |
| Details | binding site for residue 5WF C 701 |
| Chain | Residue |
| C | LEU408 |
| C | GLU475 |
| C | MET477 |
| C | GLY480 |
| C | CYS481 |
| C | ASN484 |
| C | SER538 |
| C | ASP539 |
| C | PHE540 |
| C | LEU542 |
| C | HOH907 |
| C | ALA428 |
| C | HOH918 |
| C | LYS430 |
| C | PHE442 |
| C | MET449 |
| C | MET450 |
| C | LEU460 |
| C | ILE472 |
| C | THR474 |
| site_id | AC2 |
| Number of Residues | 10 |
| Details | binding site for residue 5WE C 702 |
| Chain | Residue |
| C | TRP421 |
| C | TYR425 |
| C | SER453 |
| C | TYR461 |
| C | HOH817 |
| C | HOH873 |
| C | HOH906 |
| C | HOH927 |
| C | HOH946 |
| D | 5WE703 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | binding site for residue CL C 703 |
| Chain | Residue |
| C | GLU407 |
| C | GLY409 |
| C | VAL416 |
| C | LYS417 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | binding site for residue CL D 701 |
| Chain | Residue |
| D | ARG618 |
| D | 5WE704 |
| D | 5WE705 |
| site_id | AC5 |
| Number of Residues | 20 |
| Details | binding site for residue 5WF D 702 |
| Chain | Residue |
| D | LEU408 |
| D | VAL416 |
| D | ALA428 |
| D | LYS430 |
| D | PHE442 |
| D | MET449 |
| D | LEU460 |
| D | ILE472 |
| D | THR474 |
| D | GLU475 |
| D | MET477 |
| D | GLY480 |
| D | CYS481 |
| D | ASN484 |
| D | SER538 |
| D | ASP539 |
| D | PHE540 |
| D | LEU542 |
| D | HOH888 |
| D | HOH909 |
| site_id | AC6 |
| Number of Residues | 9 |
| Details | binding site for residue 5WE D 703 |
| Chain | Residue |
| C | 5WE702 |
| D | TRP421 |
| D | TYR425 |
| D | SER453 |
| D | GLN459 |
| D | TYR461 |
| D | HOH808 |
| D | HOH839 |
| D | HOH915 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | binding site for residue 5WE D 704 |
| Chain | Residue |
| D | GLU624 |
| D | CL701 |
| D | 5WE705 |
| D | HOH857 |
| D | HOH903 |
| site_id | AC8 |
| Number of Residues | 11 |
| Details | binding site for residue 5WE D 705 |
| Chain | Residue |
| D | ARG618 |
| D | GLU624 |
| D | TYR627 |
| D | THR628 |
| D | TYR631 |
| D | CL701 |
| D | 5WE704 |
| D | HOH901 |
| D | HOH903 |
| D | HOH949 |
| D | HOH953 |
| site_id | AC9 |
| Number of Residues | 3 |
| Details | binding site for residue EDO D 706 |
| Chain | Residue |
| D | THR403 |
| D | PHE404 |
| D | HOH978 |
Functional Information from PROSITE/UniProt
| site_id | PS00107 |
| Number of Residues | 23 |
| Details | PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGTGQFGVVKyGkwrgqyd...........VAIK |
| Chain | Residue | Details |
| C | LEU408-LYS430 |
| site_id | PS00109 |
| Number of Residues | 13 |
| Details | PROTEIN_KINASE_TYR Tyrosine protein kinases specific active-site signature. FLHrDLAARNCLV |
| Chain | Residue | Details |
| C | PHE517-VAL529 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 14 |
| Details | Motif: {"description":"CAV1-binding"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10028","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 18 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"20052711","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3K54","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3OCT","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"21280133","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3PIY","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"15375214","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"15375214","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
