5FBN

BTK kinase domain with inhibitor 1

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	C, D	Tyrosine-protein kinase BTK	polymer	271	31598.3	2	UniProt (Q06187) Pfam (PF07714) In PDB	Homo sapiens (Human)	Agammaglobulinemia tyrosine kinase,ATK,B-cell progenitor kinase,BPK,Bruton tyrosine kinase
2	C, D	4-[8-azanyl-3-[(3~{R})-1-(3-methyloxetan-3-yl)carbonylpiperidin-3-yl]imidazo[1,5-a]pyrazin-1-yl]-~{N}-[4-(trifluoromethyl)pyridin-2-yl]benzamide	non-polymer		579.6	2	Chemie (5WF)
3	C, D	4-[8-azanyl-3-[(2~{S})-1-[4-(dimethylamino)butanoyl]pyrrolidin-2-yl]imidazo[1,5-a]pyrazin-1-yl]-~{N}-(1,3-thiazol-2-yl)benzamide	non-polymer		518.6	4	Chemie (5WE)
4	C, D	CHLORIDE ION	non-polymer		35.5	2	Chemie (CL)
5	D	1,2-ETHANEDIOL	non-polymer		62.1	1	Chemie (EDO)
6		water	water		18.0	517	Chemie (HOH)

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	63196.6
Non-Polymers*	Number of molecules	9
	Total formula weight	3366.7
All*	Total formula weight	66563.2

*Water molecules are not included.