7VV6

Cryo-EM structure of pseudoallergen receptor MRGPRX2 complex with C48/80 (local)

Summary for 7VV6

• Entry DOI: 10.2210/pdb7vv6/pdb
• EMDB information: 32139
• Descriptor: Mas-related G-protein coupled receptor member X2, CHOLESTEROL, 2-[4-methoxy-3-[[2-methoxy-3-[[2-methoxy-5-[2-(methylamino)ethyl]phenyl]methyl]-5-[2-(methylamino)ethyl]phenyl]methyl]phenyl]-~{N}-methyl-ethanamine (3 entities in total)
• Functional Keywords: g protein-coupled receptor, membrane protein
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 38030.36

Authors

Li, Y.,Yang, F. (deposition date: 2021-11-04, release date: 2021-12-01, Last modification date: 2022-07-20)

• Primary citation: Yang, F.,Guo, L.,Li, Y.,Wang, G.,Wang, J.,Zhang, C.,Fang, G.X.,Chen, X.,Liu, L.,Yan, X.,Liu, Q.,Qu, C.,Xu, Y.,Xiao, P.,Zhu, Z.,Li, Z.,Zhou, J.,Yu, X.,Gao, N.,Sun, J.P.; Structure, function and pharmacology of human itch receptor complexes.; Nature, 600:164-169, 2021; PubMed: 34789875; DOI: 10.1038/s41586-021-04077-y

Experimental method

ELECTRON MICROSCOPY (3.3 Å)