7VV6

Cryo-EM structure of pseudoallergen receptor MRGPRX2 complex with C48/80 (local)

Functional Information from GO Data

Chain	GOid	namespace	contents
R	0001819	biological_process	positive regulation of cytokine production
R	0004930	molecular_function	G protein-coupled receptor activity
R	0004985	molecular_function	G protein-coupled opioid receptor activity
R	0005886	cellular_component	plasma membrane
R	0007165	biological_process	signal transduction
R	0007186	biological_process	G protein-coupled receptor signaling pathway
R	0007193	biological_process	adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
R	0007200	biological_process	phospholipase C-activating G protein-coupled receptor signaling pathway
R	0016020	cellular_component	membrane
R	0016477	biological_process	cell migration
R	0016493	molecular_function	C-C chemokine receptor activity
R	0019233	biological_process	sensory perception of pain
R	0030431	biological_process	sleep
R	0032467	biological_process	positive regulation of cytokinesis
R	0032722	biological_process	positive regulation of chemokine production
R	0038003	biological_process	G protein-coupled opioid receptor signaling pathway
R	0042923	molecular_function	neuropeptide binding
R	0043303	biological_process	mast cell degranulation
R	0045576	biological_process	mast cell activation
R	0048265	biological_process	response to pain
R	0070098	biological_process	chemokine-mediated signaling pathway
R	1902624	biological_process	positive regulation of neutrophil migration
R	1990595	molecular_function	mast cell secretagogue receptor activity

Functional Information from PROSITE/UniProt

site_id	PS00237
Number of Residues	17
Details	G_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. AGLsMLSTVSTERCLsV

Chain	Residue	Details
R	ALA115-VAL131

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	27
Details	Transmembrane: {"description":"Helical; Name=1","evidences":[{"source":"PubMed","id":"34789874","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34789875","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7S8L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7S8M","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7S8N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7S8O","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7VDH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7VDL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7VDM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7VUY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7VUZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7VV0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7VV3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7VV4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7VV5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7VV6","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	32
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"34789874","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34789875","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7S8L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7S8M","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7S8N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7S8O","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7VDH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7VDL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7VDM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7VUY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7VUZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7VV0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7VV3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7VV4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7VV5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7VV6","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	29
Details	Transmembrane: {"description":"Helical; Name=2","evidences":[{"source":"PubMed","id":"34789874","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34789875","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7S8L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7S8M","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7S8N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7S8O","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7VDH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7VDL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7VDM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7VUY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7VUZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7VV0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7VV3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7VV4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7VV5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7VV6","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	20
Details	Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"34789874","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34789875","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7S8L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7S8M","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7S8N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7S8O","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7VDH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7VDL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7VDM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7VUY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7VUZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7VV0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7VV3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7VV4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7VV5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7VV6","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	26
Details	Transmembrane: {"description":"Helical; Name=3","evidences":[{"source":"PubMed","id":"34789874","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34789875","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7S8L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7S8M","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7S8N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7S8O","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7VDH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7VDL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7VDM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7VUY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7VUZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7VV0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7VV3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7VV4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7VV5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7VV6","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	25
Details	Transmembrane: {"description":"Helical; Name=4","evidences":[{"source":"PubMed","id":"34789874","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34789875","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7S8L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7S8M","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7S8N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7S8O","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7VDH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7VDL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7VDM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7VUY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7VUZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7VV0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7VV3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7VV4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7VV5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7VV6","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	28
Details	Transmembrane: {"description":"Helical; Name=5","evidences":[{"source":"PubMed","id":"34789874","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34789875","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7S8L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7S8M","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7S8N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7S8O","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7VDH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7VDL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7VDM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7VUY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7VUZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7VV0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7VV3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7VV4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7VV5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7VV6","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	29
Details	Transmembrane: {"description":"Helical; Name=6","evidences":[{"source":"PubMed","id":"34789874","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34789875","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7S8L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7S8M","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7S8N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7S8O","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7VDH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7VDL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7VDM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7VUY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7VUZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7VV0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7VV3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7VV4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7VV5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7VV6","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	26
Details	Transmembrane: {"description":"Helical; Name=7","evidences":[{"source":"PubMed","id":"34789874","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"34789875","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7S8L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7S8M","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7S8N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7S8O","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7VDH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7VDL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7VDM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7VUY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7VUZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7VV0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7VV3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7VV4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7VV5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7VV6","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---