7VDM

Cryo-EM structure of pseudoallergen receptor MRGPRX2 complex with substance P

Summary for 7VDM

• Entry DOI: 10.2210/pdb7vdm/pdb
• EMDB information: 31923
• Descriptor: Guanine nucleotide-binding protein G(i) subunit alpha-1, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... (7 entities in total)
• Functional Keywords: g protein-coupled receptor, membrane protein
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 6
• Total formula weight: 155432.76

Authors

Li, Y.,Yang, F. (deposition date: 2021-09-07, release date: 2021-12-01, Last modification date: 2022-07-20)

• Primary citation: Yang, F.,Guo, L.,Li, Y.,Wang, G.,Wang, J.,Zhang, C.,Fang, G.X.,Chen, X.,Liu, L.,Yan, X.,Liu, Q.,Qu, C.,Xu, Y.,Xiao, P.,Zhu, Z.,Li, Z.,Zhou, J.,Yu, X.,Gao, N.,Sun, J.P.; Structure, function and pharmacology of human itch receptor complexes.; Nature, 600:164-169, 2021; PubMed: 34789875; DOI: 10.1038/s41586-021-04077-y

Experimental method

ELECTRON MICROSCOPY (2.98 Å)