2EA2
h-MetAP2 complexed with A773812
Summary for 2EA2
Entry DOI | 10.2210/pdb2ea2/pdb |
Related | 1YW7 1YW8 1YW9 2EA4 2GA2 |
Descriptor | Methionine aminopeptidase 2, MANGANESE (II) ION, 3-ETHYL-6-{[(4-FLUOROPHENYL)SULFONYL]AMINO}-2-METHYLBENZOIC ACID, ... (4 entities in total) |
Functional Keywords | protein-ligand complex, hydrolase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 41817.25 |
Authors | Park, C.H. (deposition date: 2007-01-30, release date: 2008-02-05, Last modification date: 2023-10-25) |
Primary citation | Wang, G.T.,Mantei, R.A.,Kawai, M.,Tedrow, J.S.,Barnes, D.M.,Wang, J.,Zhang, Q.,Lou, P.,Garcia, L.A.,Bouska, J.,Yates, M.,Park, C.,Judge, R.A.,Lesniewski, R.,Sheppard, G.S.,Bell, R.L. Lead optimization of methionine aminopeptidase-2 (MetAP2) inhibitors containing sulfonamides of 5,6-disubstituted anthranilic acids Bioorg.Med.Chem.Lett., 17:2817-2822, 2007 Cited by PubMed: 17350258DOI: 10.1016/j.bmcl.2007.02.062 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
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