h-MetAP2 complexed with A773812

Summary for 2EA2

Related1YW7 1YW8 1YW9 2GA2 2EA4
DescriptorMethionine aminopeptidase 2, MANGANESE (II) ION, 3-ETHYL-6-{[(4-FLUOROPHENYL)SULFONYL]AMINO}-2-METHYLBENZOIC ACID, ... (4 entities in total)
Functional Keywordsprotein-ligand complex, hydrolase
Biological sourceHomo sapiens (human)
Total number of polymer chains1
Total molecular weight41817.25
Park, C.H. (deposition date: 2007-01-30, release date: 2008-02-05, Last modification date: 2011-07-13)
Primary citation
Wang, G.T.,Mantei, R.A.,Kawai, M.,Tedrow, J.S.,Barnes, D.M.,Wang, J.,Zhang, Q.,Lou, P.,Garcia, L.A.,Bouska, J.,Yates, M.,Park, C.,Judge, R.A.,Lesniewski, R.,Sheppard, G.S.,Bell, R.L.
Lead optimization of methionine aminopeptidase-2 (MetAP2) inhibitors containing sulfonamides of 5,6-disubstituted anthranilic acids
Bioorg.Med.Chem.Lett., 17:2817-2822, 2007
PubMed: 17350258 (PDB entries with the same primary citation)
DOI: 10.1016/j.bmcl.2007.02.062
MImport into Mendeley
Experimental method

Structure validation

ClashscoreRamachandran outliersSidechain outliers172.5%2.5%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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