2EA4

h-MetAP2 complexed with A797859

Summary for 2EA4

• Entry DOI: 10.2210/pdb2ea4/pdb
• Related: 1YW7 1YW8 1YW9 2EA2 2GA2
• Descriptor: Methionine aminopeptidase 2, MANGANESE (II) ION, 2-(2-AMINOETHOXY)-3-ETHYL-6-{[(4-FLUOROPHENYL)SULFONYL]AMINO}BENZOIC ACID, ... (4 entities in total)
• Functional Keywords: protein-ligand complex, hydrolase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 41862.29

Authors

Park, C.H. (deposition date: 2007-01-30, release date: 2008-02-05, Last modification date: 2023-10-25)

• Primary citation: Wang, G.T.,Mantei, R.A.,Kawai, M.,Tedrow, J.S.,Barnes, D.M.,Wang, J.,Zhang, Q.,Lou, P.,Garcia, L.A.,Bouska, J.,Yates, M.,Park, C.,Judge, R.A.,Lesniewski, R.,Sheppard, G.S.,Bell, R.L.; Lead optimization of methionine aminopeptidase-2 (MetAP2) inhibitors containing sulfonamides of 5,6-disubstituted anthranilic acids; Bioorg.Med.Chem.Lett., 17:2817-2822, 2007; PubMed: 17350258; DOI: 10.1016/j.bmcl.2007.02.062

Experimental method

X-RAY DIFFRACTION (2.35 Å)