7VUN
 
 | | Design, modification, evaluation and cocrystal studies of novel phthalimides regulating PD-1/PD-L1 interaction | | 分子名称: | (2~{S},3~{S})-2-[[6-[(3-cyanophenyl)methoxy]-2-(2-methyl-3-phenyl-phenyl)-1,3-bis(oxidanylidene)isoindol-5-yl]methylamino]-3-oxidanyl-butanoic acid, Programmed cell death 1 ligand 1 | | 著者 | Cheng, Y, Sun, C.L, Chen, M.R, Yang, P, Xiao, Y.B. | | 登録日 | 2021-11-03 | | 公開日 | 2022-09-14 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.701 Å) | | 主引用文献 | Novel phthalimides regulating PD-1/PD-L1 interaction as potential immunotherapy agents.
Acta Pharm Sin B, 12, 2022
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7DY7
 | | Discovery of Novel Small-molecule Inhibitors of PD-1/PD-L1 Axis that Promotes PD-L1 Internalization and Degradation | | 分子名称: | 2-[[3-[[5-(2-methyl-3-phenyl-phenyl)-1,3,4-oxadiazol-2-yl]amino]phenyl]methylamino]ethanol, Programmed cell death 1 ligand 1 | | 著者 | Cheng, Y, Wang, T.Y, Lu, M.L, Jiang, S, Xiao, Y.B. | | 登録日 | 2021-01-20 | | 公開日 | 2022-01-26 | | 最終更新日 | 2024-10-16 | | 実験手法 | X-RAY DIFFRACTION (2.42 Å) | | 主引用文献 | Discovery of Small-Molecule Inhibitors of the PD-1/PD-L1 Axis That Promote PD-L1 Internalization and Degradation.
J.Med.Chem., 65, 2022
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8JMV
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8JMW
 | | Fibril form of serine peptidase Vpr | | 分子名称: | S8 family serine peptidase | | 著者 | Cao, Q, Cheng, Y. | | 登録日 | 2023-06-05 | | 公開日 | 2023-12-06 | | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | | 主引用文献 | Serine peptidase Vpr forms enzymatically active fibrils outside Bacillus bacteria revealed by cryo-EM.
Nat Commun, 14, 2023
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4JZA
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7RPK
 | | Cryo-EM structure of murine Dispatched in complex with Sonic hedgehog | | 分子名称: | (2S)-3-{[(S)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-2-(hexanoyloxy)propyl hexanoate, 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | | 著者 | Asarnow, D, Wang, Q, Ding, K, Cheng, Y, Beachy, P.A. | | 登録日 | 2021-08-03 | | 公開日 | 2021-10-27 | | 最終更新日 | 2023-12-13 | | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | | 主引用文献 | Dispatched uses Na + flux to power release of lipid-modified Hedgehog.
Nature, 599, 2021
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7RPJ
 | | Cryo-EM structure of murine Dispatched NNN mutant | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL HEMISUCCINATE, Protein dispatched homolog 1 | | 著者 | Asarnow, D, Wang, Q, Ding, K, Cheng, Y, Beachy, P.A. | | 登録日 | 2021-08-03 | | 公開日 | 2021-10-27 | | 最終更新日 | 2021-11-24 | | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | | 主引用文献 | Dispatched uses Na + flux to power release of lipid-modified Hedgehog.
Nature, 599, 2021
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7RPH
 | | Cryo-EM structure of murine Dispatched 'R' conformation | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL HEMISUCCINATE, Lauryl Maltose Neopentyl Glycol, ... | | 著者 | Asarnow, D, Wang, Q, Ding, K, Cheng, Y, Beachy, P.A. | | 登録日 | 2021-08-03 | | 公開日 | 2021-10-27 | | 最終更新日 | 2023-12-13 | | 実験手法 | ELECTRON MICROSCOPY (2.5 Å) | | 主引用文献 | Dispatched uses Na + flux to power release of lipid-modified Hedgehog.
Nature, 599, 2021
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7RPI
 | | Cryo-EM structure of murine Dispatched 'T' conformation | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL HEMISUCCINATE, Lauryl Maltose Neopentyl Glycol, ... | | 著者 | Asarnow, D, Wang, Q, Ding, K, Cheng, Y, Beachy, P.A. | | 登録日 | 2021-08-03 | | 公開日 | 2021-10-27 | | 最終更新日 | 2023-12-13 | | 実験手法 | ELECTRON MICROSCOPY (2.5 Å) | | 主引用文献 | Dispatched uses Na + flux to power release of lipid-modified Hedgehog.
Nature, 599, 2021
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5IRX
 | | Structure of TRPV1 in complex with DkTx and RTX, determined in lipid nanodisc | | 分子名称: | (2S)-2-(acetyloxy)-3-{[(R)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}propyl pentanoate, (2S)-3-{[(S)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-2-(hexanoyloxy)propyl hexanoate, (4R,7S)-4-hydroxy-N,N,N-trimethyl-4,9-dioxo-7-[(pentanoyloxy)methyl]-3,5,8-trioxa-4lambda~5~-phosphatetradecan-1-aminium, ... | | 著者 | Gao, Y, Cao, E, Julius, D, Cheng, Y. | | 登録日 | 2016-03-14 | | 公開日 | 2016-05-25 | | 最終更新日 | 2019-12-18 | | 実験手法 | ELECTRON MICROSCOPY (2.95 Å) | | 主引用文献 | TRPV1 structures in nanodiscs reveal mechanisms of ligand and lipid action.
Nature, 534, 2016
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5IS0
 | | Structure of TRPV1 in complex with capsazepine, determined in lipid nanodisc | | 分子名称: | Transient receptor potential cation channel subfamily V member 1, capsazepine | | 著者 | Gao, Y, Cao, E, Julius, D, Cheng, Y. | | 登録日 | 2016-03-15 | | 公開日 | 2016-05-25 | | 最終更新日 | 2024-03-06 | | 実験手法 | ELECTRON MICROSCOPY (3.43 Å) | | 主引用文献 | TRPV1 structures in nanodiscs reveal mechanisms of ligand and lipid action.
Nature, 534, 2016
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5IRZ
 | | Structure of TRPV1 determined in lipid nanodisc | | 分子名称: | (2S)-1-{[(R)-hydroxy{[(1R,2R,3S,4S,5S,6S)-2,3,4,5,6-pentahydroxycyclohexyl]oxy}phosphoryl]oxy}-3-(pentanoyloxy)propan-2-yl decanoate, (2S)-3-{[(S)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-2-(hexanoyloxy)propyl hexanoate, (4R,7S)-4-hydroxy-N,N,N-trimethyl-4,9-dioxo-7-[(pentanoyloxy)methyl]-3,5,8-trioxa-4lambda~5~-phosphatetradecan-1-aminium, ... | | 著者 | Gao, Y, Cao, E, Julius, D, Cheng, Y. | | 登録日 | 2016-03-15 | | 公開日 | 2016-05-25 | | 最終更新日 | 2024-03-06 | | 実験手法 | ELECTRON MICROSCOPY (3.28 Å) | | 主引用文献 | TRPV1 structures in nanodiscs reveal mechanisms of ligand and lipid action.
Nature, 534, 2016
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1XI5
 | | Clathrin D6 coat with auxilin J-domain | | 分子名称: | Auxilin J-domain, Clathrin heavy chain | | 著者 | Fotin, A, Cheng, Y, Grigorieff, N, Walz, T, Harrison, S.C, Kirchhausen, T. | | 登録日 | 2004-09-21 | | 公開日 | 2004-11-02 | | 最終更新日 | 2024-03-13 | | 実験手法 | ELECTRON MICROSCOPY (12 Å) | | 主引用文献 | Structure of an auxilin-bound clathrin coat and its implications for the mechanism of uncoating
Nature, 432, 2004
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1XI4
 | | Clathrin D6 Coat | | 分子名称: | Clathrin heavy chain, Clathrin light chain A | | 著者 | Fotin, A, Cheng, Y, Sliz, P, Grigorieff, N, Harrison, S.C, Kirchhausen, T, Walz, T. | | 登録日 | 2004-09-21 | | 公開日 | 2004-11-02 | | 最終更新日 | 2024-03-13 | | 実験手法 | ELECTRON MICROSCOPY (7.9 Å) | | 主引用文献 | Molecular model for a complete clathrin lattice from electron cryomicroscopy
Nature, 432, 2004
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8SBE
 | | Structure of the rat vesicular glutamate transporter 2 determined by single-particle Cryo-EM | | 分子名称: | Vesicular glutamate transporter 2 | | 著者 | Li, F, Finer-Moore, J, Eriksen, J, Cheng, Y, Edwards, R, Stroud, R. | | 登録日 | 2023-04-03 | | 公開日 | 2023-05-03 | | 最終更新日 | 2024-06-19 | | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | | 主引用文献 | Ion transport and regulation in a synaptic vesicle glutamate transporter.
Science, 368, 2020
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6A0P
 | | Crystal structure of Usutu virus envelope protein in the pre-fusion state | | 分子名称: | Envelope protein | | 著者 | Lu, G, Chen, Z, Ye, F, Lin, S, Yang, F, Cheng, Y. | | 登録日 | 2018-06-06 | | 公開日 | 2018-12-26 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Crystal structure of Usutu virus envelope protein in the pre-fusion state
Virol. J., 15, 2018
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7T9I
 | | Native human TSH bound to human Thyrotropin receptor in complex with miniGs399 (composite structure) | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Glycoprotein hormones alpha chain, ... | | 著者 | Faust, B, Cheng, Y, Manglik, A. | | 登録日 | 2021-12-19 | | 公開日 | 2022-08-03 | | 最終更新日 | 2022-10-05 | | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | | 主引用文献 | Autoantibody mimicry of hormone action at the thyrotropin receptor.
Nature, 609, 2022
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7T9N
 | | M22 Agonist Autoantibody bound to Human Thyrotropin receptor in complex with miniGs399 (composite structure) | | 分子名称: | (2S)-3-hydroxypropane-1,2-diyl dihexadecanoate, 2-acetamido-2-deoxy-beta-D-glucopyranose, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | 著者 | Faust, B, Cheng, Y, Manglik, A. | | 登録日 | 2021-12-19 | | 公開日 | 2022-08-03 | | 最終更新日 | 2022-10-05 | | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | | 主引用文献 | Autoantibody mimicry of hormone action at the thyrotropin receptor.
Nature, 609, 2022
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7T9M
 | | Human Thyrotropin receptor bound by CS-17 Inverse Agonist Fab/Org 274179-0 Antagonist | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CS-17 Heavy Chain, ... | | 著者 | Faust, B, Cheng, Y, Manglik, A. | | 登録日 | 2021-12-19 | | 公開日 | 2022-08-10 | | 最終更新日 | 2024-10-09 | | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | | 主引用文献 | Autoantibody mimicry of hormone action at the thyrotropin receptor.
Nature, 609, 2022
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7UTZ
 | | Human thyrotropin analog TR1402 bound to human Thyrotropin receptor in complex with miniGs399 (composite structure) | | 分子名称: | (2S)-3-hydroxypropane-1,2-diyl dihexadecanoate, 2-acetamido-2-deoxy-beta-D-glucopyranose, Glycoprotein hormones alpha chain analog TR1402, ... | | 著者 | Faust, B, Cheng, Y, Manglik, A. | | 登録日 | 2022-04-28 | | 公開日 | 2022-08-03 | | 最終更新日 | 2022-10-05 | | 実験手法 | ELECTRON MICROSCOPY (2.4 Å) | | 主引用文献 | Autoantibody mimicry of hormone action at the thyrotropin receptor.
Nature, 609, 2022
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1Q57
 | | The Crystal Structure of the Bifunctional Primase-Helicase of Bacteriophage T7 | | 分子名称: | DNA primase/helicase | | 著者 | Toth, E.A, Li, Y, Sawaya, M.R, Cheng, Y, Ellenberger, T. | | 登録日 | 2003-08-06 | | 公開日 | 2003-11-25 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (3.45 Å) | | 主引用文献 | The Crystal Structure of the Bifunctional Primase-Helicase of Bacteriophage T7
Mol.Cell, 12, 2003
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7RMI
 | | SP6-11 biased agonist bound to active human neurokinin 1 receptor in complex with miniGs/q70 | | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... | | 著者 | Harris, J.A, Faust, B, Gondin, A.B, Daemgen, M.A, Suomivuori, C.M, Veldhuis, N.A, Cheng, Y, Dror, R.O, Thal, D, Manglik, A. | | 登録日 | 2021-07-27 | | 公開日 | 2021-11-03 | | 最終更新日 | 2022-01-05 | | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | | 主引用文献 | Selective G protein signaling driven by substance P-neurokinin receptor dynamics.
Nat.Chem.Biol., 18, 2022
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7RMG
 | | Substance P bound to active human neurokinin 1 receptor in complex with miniGs/q70 | | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... | | 著者 | Harris, J.A, Faust, B, Gondin, A.B, Daemgen, M.A, Suomivuori, C.M, Veldhuis, N.A, Cheng, Y, Dror, R.O, Thal, D, Manglik, A. | | 登録日 | 2021-07-27 | | 公開日 | 2021-11-03 | | 最終更新日 | 2022-01-05 | | 実験手法 | ELECTRON MICROSCOPY (3 Å) | | 主引用文献 | Selective G protein signaling driven by substance P-neurokinin receptor dynamics.
Nat.Chem.Biol., 18, 2022
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7RMH
 | | Substance P bound to active human neurokinin 1 receptor in complex with miniGs399 | | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... | | 著者 | Harris, J.A, Faust, B, Gondin, A.B, Daemgen, M.A, Suomivuori, C.M, Veldhuis, N.A, Cheng, Y, Dror, R.O, Thal, D, Manglik, A. | | 登録日 | 2021-07-27 | | 公開日 | 2021-11-03 | | 最終更新日 | 2022-01-05 | | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | | 主引用文献 | Selective G protein signaling driven by substance P-neurokinin receptor dynamics.
Nat.Chem.Biol., 18, 2022
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6D7W
 | | Cryo-EM structure of the mitochondrial calcium uniporter from N. fischeri at 3.8 Angstrom resolution | | 分子名称: | CALCIUM ION, Mitochondrial calcium uniporter | | 著者 | Nguyen, N.X, Armache, J.-P, Cheng, Y, Bai, X.C. | | 登録日 | 2018-04-25 | | 公開日 | 2018-07-11 | | 最終更新日 | 2024-05-15 | | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | | 主引用文献 | Cryo-EM structure of a fungal mitochondrial calcium uniporter.
Nature, 559, 2018
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