7RPK

Cryo-EM structure of murine Dispatched in complex with Sonic hedgehog

Summary for 7RPK

• Entry DOI: 10.2210/pdb7rpk/pdb
• EMDB information: 24614 24615 24616 24617
• Descriptor: Protein dispatched homolog 1, SULFATE ION, Sonic hedgehog protein, ... (11 entities in total)
• Functional Keywords: rnd transporter, hedgehog binding, sterol sensing domain, sodium binding, membrane protein
• Biological source: Mus musculus (Mouse); More
• Total number of polymer chains: 2
• Total formula weight: 187273.56

Authors

Asarnow, D.,Wang, Q.,Ding, K.,Cheng, Y.,Beachy, P.A. (deposition date: 2021-08-03, release date: 2021-10-27, Last modification date: 2023-12-13)

• Primary citation: Wang, Q.,Asarnow, D.E.,Ding, K.,Mann, R.K.,Hatakeyama, J.,Zhang, Y.,Ma, Y.,Cheng, Y.,Beachy, P.A.; Dispatched uses Na + flux to power release of lipid-modified Hedgehog.; Nature, 599:320-324, 2021; PubMed: 34707294; DOI: 10.1038/s41586-021-03996-0

Experimental method

ELECTRON MICROSCOPY (2.7 Å)