7RPK
Cryo-EM structure of murine Dispatched in complex with Sonic hedgehog
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Protein dispatched homolog 1 | polymer | 1352 | 152071.1 | 1 | UniProt (Q3TDN0) Pfam (PF02460) In PDB | Mus musculus (Mouse) | Mdispa |
| 2 | H | Sonic hedgehog protein | polymer | 164 | 18732.1 | 1 | UniProt (Q62226) Pfam (PF01085) In PDB | Mus musculus (Mouse) | ShhN,Shh N-terminal processed signaling domains,ShhNp,Sonic hedgehog protein 19 kDa product |
| 3 | A | CHOLESTEROL HEMISUCCINATE | non-polymer | 486.7 | 26 | Chemie (Y01) | |||
| 4 | A | Lauryl Maltose Neopentyl Glycol | non-polymer | 1005.2 | 2 | Chemie (AV0) | |||
| 5 | A | SODIUM ION | non-polymer | 23.0 | 2 | Chemie (NA) | |||
| 6 | A | (2S)-3-{[(S)-(2-aminoethoxy)(hydroxy)phosphoryl]oxy}-2-(hexanoyloxy)propyl hexanoate | non-polymer | 411.4 | 1 | Chemie (6OE) | |||
| 7 | A | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 5 | Chemie (NAG) | |||
| 8 | H | CALCIUM ION | non-polymer | 40.1 | 2 | Chemie (CA) | |||
| 9 | H | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 10 | H | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) | |||
| 11 | water | water | 18.0 | 42 | Chemie (HOH) |
Sequence modifications
A: 172 - 1521 (UniProt: Q3TDN0)
| PDB | External Database | Details |
|---|---|---|
| Met 170 | - | expression tag |
| Ala 171 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 170803.2 | |
| Non-Polymers* | Number of molecules | 40 |
| Total formula weight | 16470.3 | |
| All* | Total formula weight | 187273.6 |
