7DY7
Discovery of Novel Small-molecule Inhibitors of PD-1/PD-L1 Axis that Promotes PD-L1 Internalization and Degradation
Summary for 7DY7
| Entry DOI | 10.2210/pdb7dy7/pdb |
| Descriptor | Programmed cell death 1 ligand 1, 2-[[3-[[5-(2-methyl-3-phenyl-phenyl)-1,3,4-oxadiazol-2-yl]amino]phenyl]methylamino]ethanol (3 entities in total) |
| Functional Keywords | immune checkpoint, inhibitor, complex, dimer, immunosuppressant |
| Biological source | Homo sapiens (Human) |
| Total number of polymer chains | 2 |
| Total formula weight | 29205.40 |
| Authors | Cheng, Y.,Wang, T.Y.,Lu, M.L.,Jiang, S.,Xiao, Y.B. (deposition date: 2021-01-20, release date: 2022-01-26, Last modification date: 2023-11-29) |
| Primary citation | Wang, T.,Cai, S.,Cheng, Y.,Zhang, W.,Wang, M.,Sun, H.,Guo, B.,Li, Z.,Xiao, Y.,Jiang, S. Discovery of Small-Molecule Inhibitors of the PD-1/PD-L1 Axis That Promote PD-L1 Internalization and Degradation. J.Med.Chem., 65:3879-3893, 2022 Cited by PubMed: 35188766DOI: 10.1021/acs.jmedchem.1c01682 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.42 Å) |
Structure validation
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