7DY7
Discovery of Novel Small-molecule Inhibitors of PD-1/PD-L1 Axis that Promotes PD-L1 Internalization and Degradation
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | B, A | Programmed cell death 1 ligand 1 | polymer | 126 | 14402.5 | 2 | UniProt (Q9NZQ7) Pfam (PF07686) In PDB | Homo sapiens (Human) | hPD-L1,B7 homolog 1,B7-H1 |
2 | B | 2-[[3-[[5-(2-methyl-3-phenyl-phenyl)-1,3,4-oxadiazol-2-yl]amino]phenyl]methylamino]ethanol | non-polymer | 400.5 | 1 | Chemie (HOU) | |||
3 | water | water | 18.0 | 4 | Chemie (HOH) |
Sequence modifications
B, A: 18 - 134 (UniProt: Q9NZQ7)
PDB | External Database | Details |
---|---|---|
Ala 135 | - | expression tag |
Ala 136 | - | expression tag |
Ala 137 | - | expression tag |
Leu 138 | - | expression tag |
Glu 139 | - | expression tag |
His 140 | - | expression tag |
His 141 | - | expression tag |
His 142 | - | expression tag |
His 143 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 28804.9 | |
Non-Polymers* | Number of molecules | 1 |
Total formula weight | 400.5 | |
All* | Total formula weight | 29205.4 |