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8GTT
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BU of 8gtt by Molmil
Cryo-EM structure of human Pannexin1 resembling Pannexin2 pore with W74R/R75Dmutations
Descriptor: Pannexin-1
Authors:Hussain, N, Penmatsa, A.
Deposit date:2022-09-08
Release date:2024-02-28
Last modified:2024-06-19
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Cryo-EM structures of pannexin 1 and 3 reveal differences among pannexin isoforms.
Nat Commun, 15, 2024
2ZEU
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BU of 2zeu by Molmil
S. Cerevisiae Geranylgeranyl Pyrophosphate Synthase in Complex with BPH-715
Descriptor: 3-(DECYLOXY)-1-(2,2-DIPHOSPHONOETHYL)PYRIDINIUM, Geranylgeranyl pyrophosphate synthetase
Authors:Guo, R.T, Chen, C.K.-M, Cao, R, Oldfield, E, Wang, A.H.-J.
Deposit date:2007-12-17
Release date:2008-12-23
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2 Å)
Cite:Lipophilic bisphosphonates as dual farnesyl/geranylgeranyl diphosphate synthase inhibitors: an X-ray and NMR investigation
J.Am.Chem.Soc., 131, 2009
2ZEV
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BU of 2zev by Molmil
S. Cerevisiae Geranylgeranyl Pyrophosphate Synthase in Complex with Magnesium, IPP and BPH-715
Descriptor: 3-(DECYLOXY)-1-(2,2-DIPHOSPHONOETHYL)PYRIDINIUM, 3-METHYLBUT-3-ENYL TRIHYDROGEN DIPHOSPHATE, Geranylgeranyl pyrophosphate synthetase, ...
Authors:Guo, R.T, Chen, C.K.-M, Cao, R, Oldfield, E, Wang, A.H.-J.
Deposit date:2007-12-17
Release date:2008-12-23
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.23 Å)
Cite:Lipophilic bisphosphonates as dual farnesyl/geranylgeranyl diphosphate synthase inhibitors: an X-ray and NMR investigation
J.Am.Chem.Soc., 131, 2009
3EGT
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BU of 3egt by Molmil
T. Brucei Farnesyl Diphosphate Synthase Complexed with Bisphosphonate BPH-722
Descriptor: 1-(2,2-diphosphonoethyl)-3-(heptyloxy)pyridinium, Farnesyl pyrophosphate synthase, MAGNESIUM ION
Authors:Cao, R, Gao, Y, Robinson, H, Oldfield, E.
Deposit date:2008-09-11
Release date:2009-05-05
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2 Å)
Cite:Lipophilic bisphosphonates as dual farnesyl/geranylgeranyl diphosphate synthase inhibitors: an X-ray and NMR investigation.
J.Am.Chem.Soc., 131, 2009
3EFQ
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BU of 3efq by Molmil
T. Brucei Farnesyl Diphosphate Synthase Complexed with Bisphosphonate BPH-714
Descriptor: 1-(2,2-diphosphonoethyl)-3-(octyloxy)pyridinium, Farnesyl pyrophosphate synthase, MAGNESIUM ION
Authors:Cao, R, Gao, Y, Robinson, H, Oldfield, E.
Deposit date:2008-09-09
Release date:2009-05-05
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2 Å)
Cite:Lipophilic bisphosphonates as dual farnesyl/geranylgeranyl diphosphate synthase inhibitors: an X-ray and NMR investigation.
J.Am.Chem.Soc., 131, 2009
3DYG
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BU of 3dyg by Molmil
T. Brucei Farnesyl Diphosphate Synthase Complexed with Bisphosphonate BPH-461
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, 3-FLUORO-1-(2-HYDROXY-2,2-DIPHOSPHONOETHYL)PYRIDINIUM, ACETATE ION, ...
Authors:Cao, R, Gao, Y, Robinson, H, Goddard, A, Oldfield, E.
Deposit date:2008-07-27
Release date:2009-05-05
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Lipophilic bisphosphonates as dual farnesyl/geranylgeranyl diphosphate synthase inhibitors: an X-ray and NMR investigation.
J.Am.Chem.Soc., 131, 2009
3DYH
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BU of 3dyh by Molmil
T. Brucei Farnesyl Diphosphate Synthase Complexed with Bisphosphonate BPH-721
Descriptor: 3-butoxy-1-(2,2-diphosphonoethyl)pyridinium, Farnesyl pyrophosphate synthase, MAGNESIUM ION
Authors:Cao, R, Gao, Y, Robinson, H, Goddard, A, Oldfield, E.
Deposit date:2008-07-27
Release date:2009-05-05
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.94 Å)
Cite:Lipophilic bisphosphonates as dual farnesyl/geranylgeranyl diphosphate synthase inhibitors: an X-ray and NMR investigation.
J.Am.Chem.Soc., 131, 2009
3DYF
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BU of 3dyf by Molmil
T. Brucei Farnesyl Diphosphate Synthase Complexed with Bisphosphonate BPH-461 and Isopentyl Diphosphate
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, 3-FLUORO-1-(2-HYDROXY-2,2-DIPHOSPHONOETHYL)PYRIDINIUM, ACETATE ION, ...
Authors:Cao, R, Gao, Y, Robinson, H, Goddard, A, Oldfield, E.
Deposit date:2008-07-27
Release date:2009-05-05
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Lipophilic bisphosphonates as dual farnesyl/geranylgeranyl diphosphate synthase inhibitors: an X-ray and NMR investigation.
J.Am.Chem.Soc., 131, 2009
7RK2
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BU of 7rk2 by Molmil
Crystal structure of the human astrovirus serotype 8 capsid spike in complex with scFv 2D9, an astrovirus-neutralizing antibody, at 2.65-A resolution
Descriptor: Capsid protein VP25, scFv 2D9
Authors:Meyer, L, Cuellar, C, DuBois, R.M.
Deposit date:2021-07-21
Release date:2021-10-13
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Structures of Two Human Astrovirus Capsid/Neutralizing Antibody Complexes Reveal Distinct Epitopes and Inhibition of Virus Attachment to Cells.
J.Virol., 96, 2022
7RK1
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BU of 7rk1 by Molmil
Crystal structure of the human astrovirus serotype 8 capsid spike in complex with scFv 3E8, an astrovirus-neutralizing antibody, at 2.05-A resolution
Descriptor: Capsid polyprotein VP70, scFv 3E8
Authors:Meyer, L, DuBois, R.M.
Deposit date:2021-07-21
Release date:2021-10-13
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Structures of Two Human Astrovirus Capsid/Neutralizing Antibody Complexes Reveal Distinct Epitopes and Inhibition of Virus Attachment to Cells.
J.Virol., 96, 2022
5MAW
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BU of 5maw by Molmil
Crystal structure of the flagellin-FliS complex from Bacillus subtilis
Descriptor: Flagellar protein FliS, Flagellin
Authors:Altegoer, F, Bange, G.
Deposit date:2016-11-07
Release date:2017-12-20
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:FliS/flagellin/FliW heterotrimer couples type III secretion and flagellin homeostasis.
Sci Rep, 8, 2018
4R0I
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BU of 4r0i by Molmil
CRYSTAL STRUCTURE of MATRIPTASE in COMPLEX WITH INHIBITOR
Descriptor: 3-({(2S)-3-[4-(2-aminoethyl)piperidin-1-yl]-2-[(naphthalen-2-ylsulfonyl)amino]-3-oxopropyl}oxy)benzenecarboximidamide, SERINE PROTEASE, MATRIPTASE, ...
Authors:Rao, K.N, Ashok, K.N, Chakshusmathi, G, Rajeev, G, Subramanya, H.
Deposit date:2014-07-31
Release date:2015-02-11
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Discovery of O-(3-carbamimidoylphenyl)-l-serine amides as matriptase inhibitors using a fragment-linking approach
Bioorg.Med.Chem.Lett., 25, 2015
2OPM
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BU of 2opm by Molmil
Human Farnesyl Diphosphate Synthase Complexed with Bisphosphonate BPH-461
Descriptor: 3-FLUORO-1-(2-HYDROXY-2,2-DIPHOSPHONOETHYL)PYRIDINIUM, Farnesyl pyrophosphate synthetase (FPP synthetase) (FPS) (Farnesyl diphosphate synthetase) [Includes: Dimethylallyltranstransferase (EC 2.5.1.1); Geranyltranstransferase (EC 2.5.1.10)], MAGNESIUM ION, ...
Authors:Cao, R, Gao, Y.G, Robinson, H, Goddard, A.
Deposit date:2007-01-29
Release date:2007-12-11
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Lipophilic bisphosphonates as dual farnesyl/geranylgeranyl diphosphate synthase inhibitors: an X-ray and NMR investigation.
J.Am.Chem.Soc., 131, 2009
4L5F
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BU of 4l5f by Molmil
Crystal Structure of DENV1-E106 Fab bound to DENV-1 Envelope protein DIII
Descriptor: Envelope protein, Heavy chain of E106 antibody (VH and CH1 of IgG2c), Light chain of E106 antibody (kappa)
Authors:Edeling, M.A, Nelson, C.A, Fremont, D.H, Center for Structural Genomics of Infectious Diseases (CSGID)
Deposit date:2013-06-11
Release date:2013-12-11
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Crystal Structure of DENV1-E106 Fab bound to DENV-1 Envelope protein DIII
To be Published
4O97
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BU of 4o97 by Molmil
Crystal structure of matriptase in complex with inhibitor
Descriptor: N-(trans-4-aminocyclohexyl)-3,5-bis[(3-carbamimidoylbenzyl)oxy]benzamide, Peptide CGLR, Suppressor of tumorigenicity 14 protein
Authors:Rao, K.N, Chandra, B.R, Ashok, K.N, Chakshusmathi, G, Ramesh, K.S, Subramanya, H.S.
Deposit date:2014-01-02
Release date:2014-05-28
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structure-guided discovery of 1,3,5 tri-substituted benzenes as potent and selective matriptase inhibitors exhibiting in vivo antitumor efficacy.
Bioorg.Med.Chem., 22, 2014
4O9V
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BU of 4o9v by Molmil
Crystal structure of matriptase in complex with inhibitor
Descriptor: N-(trans-4-aminocyclohexyl)-3,5-bis(4-carbamimidoylphenoxy)benzamide, Peptide CGLR, Suppressor of tumorigenicity 14 protein
Authors:Rao, K.N, Chandra, B.R, Ashok, K.N, Chakshusmathi, G, Ramesh, K.S, Subramanya, H.S.
Deposit date:2014-01-03
Release date:2014-05-28
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structure-guided discovery of 1,3,5 tri-substituted benzenes as potent and selective matriptase inhibitors exhibiting in vivo antitumor efficacy.
Bioorg.Med.Chem., 22, 2014
4QAX
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BU of 4qax by Molmil
Crystal structure of post-catalytic binary complex of Phosphoglycerate mutase from Staphylococcus aureus
Descriptor: 2,3-bisphosphoglycerate-independent phosphoglycerate mutase, 2-PHOSPHOGLYCERIC ACID, MANGANESE (II) ION
Authors:Roychowdhury, A, Kundu, A, Bose, M, Gujar, A, Das, A.K.
Deposit date:2014-05-06
Release date:2015-05-06
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2 Å)
Cite:STRUCTURAL AND FUNCCTIONAL ANALYSIS of PHOSPHOGLYCERATE MUTASE from STAPHYLOCOCCUS AUREUS
To be Published
4RVC
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BU of 4rvc by Molmil
Structure of ATP binding subunit of ABC transporter
Descriptor: ABC transporter ATP-binding protein
Authors:Manjula, M, Pampa, K.J, Lokanath, N.K.
Deposit date:2014-11-26
Release date:2015-03-18
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.77 Å)
Cite:Crystal structure of ATP-binding subunit of an ABC transporter from Geobacillus kaustophilus.
Biochem.Biophys.Res.Commun., 459, 2015
8UCX
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BU of 8ucx by Molmil
Dihydrofolate Reductase Complexed with Folate
Descriptor: Dihydrofolate reductase, FOLIC ACID, MANGANESE (II) ION
Authors:Fried, S.D.E, Boxer, S.G.
Deposit date:2023-09-27
Release date:2023-10-11
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.57 Å)
Cite:Role of Electrostatics in Hydride Transfer by Dihydrofolate Reductase
To Be Published
2OGD
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BU of 2ogd by Molmil
T. Brucei Farnesyl Diphosphate Synthase Complexed with Bisphosphonate BPH-527
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, ACETATE ION, BETA-MERCAPTOETHANOL, ...
Authors:Cao, R, Gao, Y, Robinson, H, Goddard, A, Oldfield, E.
Deposit date:2007-01-05
Release date:2007-10-02
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2 Å)
Cite:Bisphosphonates: Teaching Old Drugs with New Tricks
TO BE PUBLISHED
4JYT
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BU of 4jyt by Molmil
Crystal Structure of Matriptase in complex with Inhibitor
Descriptor: 4,4'-[{3-[(naphthalen-2-ylsulfonyl)amino]pyridine-2,6-diyl}bis(oxy)]dibenzenecarboximidamide, Suppressor of tumorigenicity 14 protein
Authors:Subramanya, H.S, Ravi, B.C, Ashok, K.N, Chakshusmathi, G, Ramesh, K.S.
Deposit date:2013-04-01
Release date:2014-03-19
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2 Å)
Cite:Discovery of Pyridyl Bis(oxy)dibenzimidamide Derivatives as Selective Matriptase Inhibitors
ACS MED.CHEM.LETT., 4, 2013
4JZI
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BU of 4jzi by Molmil
Crystal Structure of Matriptase in complex with Inhibitor".
Descriptor: N-(trans-4-aminocyclohexyl)-2,6-bis(4-carbamimidoylphenoxy)pyridine-4-carboxamide, Suppressor of tumorigenicity 14 protein
Authors:Subramanya, H.S, Chandra, R.B, Ashok, K.N, Chakshusmathi, G, Ramesh, K.S.
Deposit date:2013-04-03
Release date:2014-02-26
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2 Å)
Cite:Discovery of Pyridyl Bis(oxy)dibenzimidamide Derivatives as Selective Matriptase Inhibitors
ACS MED.CHEM.LETT., 4, 2013
4JZ1
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BU of 4jz1 by Molmil
Crystal Structure of Matriptase in complex with Inhibitor
Descriptor: 4,4'-[(3-{[(4-fluorophenyl)sulfonyl]amino}pyridine-2,6-diyl)bis(oxy)]dibenzenecarboximidamide, Suppressor of tumorigenicity 14 protein
Authors:Subramanya, H.S, Ravi, B.C, Ashok, K.N, Chakshusmathi, G, Ramesh, K.S.
Deposit date:2013-04-02
Release date:2014-02-26
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Discovery of Pyridyl Bis(oxy)dibenzimidamide Derivatives as Selective Matriptase Inhibitors
ACS MED.CHEM.LETT., 4, 2013
2OPN
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BU of 2opn by Molmil
Human Farnesyl Diphosphate Synthase Complexed with Bisphosphonate BPH-527
Descriptor: Farnesyl pyrophosphate synthetase (FPP synthetase) (FPS) (Farnesyl diphosphate synthetase) [Includes: Dimethylallyltranstransferase (EC 2.5.1.1); Geranyltranstransferase (EC 2.5.1.10)], MAGNESIUM ION, PHOSPHATE ION, ...
Authors:Cao, R, Gao, Y.G, Robinson, H, Goddard, A, Oldfield, E.
Deposit date:2007-01-29
Release date:2007-10-02
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Bisphosphonates: Teaching Old Drugs with New Tricks
To be Published
4NWJ
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BU of 4nwj by Molmil
Crystal structure of phosphopglycerate mutase from Staphylococcus aureus in 3-phosphoglyceric acid bound form.
Descriptor: 2,3-bisphosphoglycerate-independent phosphoglycerate mutase, 3-PHOSPHOGLYCERIC ACID, MANGANESE (II) ION
Authors:Roychowdhury, A, Bose, M, Kundu, A, Gujar, A, Das, A.K.
Deposit date:2013-12-06
Release date:2015-01-14
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.01 Å)
Cite:Complete catalytic cycle of cofactor-independent phosphoglycerate mutase involves a spring-loaded mechanism
Febs J., 282, 2015

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