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4O97

Crystal structure of matriptase in complex with inhibitor

Summary for 4O97
Entry DOI10.2210/pdb4o97/pdb
Related4O9V
DescriptorSuppressor of tumorigenicity 14 protein, Peptide CGLR, N-(trans-4-aminocyclohexyl)-3,5-bis[(3-carbamimidoylbenzyl)oxy]benzamide, ... (4 entities in total)
Functional Keywordsmatriptase, trypsin-like serine proteinase fold, protease, small molecule inhibitor, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological sourceHomo sapiens (human)
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Cellular locationMembrane; Single-pass type II membrane protein (Probable): Q9Y5Y6 Q9Y5Y6
Total number of polymer chains2
Total formula weight27426.94
Authors
Rao, K.N.,Chandra, B.R.,Ashok, K.N.,Chakshusmathi, G.,Ramesh, K.S.,Subramanya, H.S. (deposition date: 2014-01-02, release date: 2014-05-28, Last modification date: 2023-11-08)
Primary citationGoswami, R.,Mukherjee, S.,Ghadiyaram, C.,Wohlfahrt, G.,Sistla, R.K.,Nagaraj, J.,Satyam, L.K.,Subbarao, K.,Palakurthy, R.K.,Gopinath, S.,Krishnamurthy, N.R.,Ikonen, T.,Moilanen, A.,Subramanya, H.S.,Kallio, P.,Ramachandra, M.
Structure-guided discovery of 1,3,5 tri-substituted benzenes as potent and selective matriptase inhibitors exhibiting in vivo antitumor efficacy.
Bioorg.Med.Chem., 22:3187-3203, 2014
Cited by
PubMed: 24794746
DOI: 10.1016/j.bmc.2014.04.013
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.2 Å)
Structure validation

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