4R0I
CRYSTAL STRUCTURE of MATRIPTASE in COMPLEX WITH INHIBITOR
Summary for 4R0I
Entry DOI | 10.2210/pdb4r0i/pdb |
Descriptor | Suppressor of tumorigenicity 14 protein, SERINE PROTEASE, MATRIPTASE, MEMBRANE-TYPE SERINE PROTEASE 1, MT-SP1, 3-({(2S)-3-[4-(2-aminoethyl)piperidin-1-yl]-2-[(naphthalen-2-ylsulfonyl)amino]-3-oxopropyl}oxy)benzenecarboximidamide, ... (4 entities in total) |
Functional Keywords | hydrolase, matriptase, complex structure, trypsin-like serine proteinase fold, protease, small molecule inhibitor |
Biological source | Homo sapiens (human) More |
Cellular location | Membrane ; Single-pass type II membrane protein : Q9Y5Y6 Q9Y5Y6 |
Total number of polymer chains | 2 |
Total formula weight | 27435.96 |
Authors | Rao, K.N.,Ashok, K.N.,Chakshusmathi, G.,Rajeev, G.,Subramanya, H. (deposition date: 2014-07-31, release date: 2015-02-11, Last modification date: 2023-11-08) |
Primary citation | Goswami, R.,Wohlfahrt, G.,Mukherjee, S.,Ghadiyaram, C.,Nagaraj, J.,Satyam, L.K.,Subbarao, K.,Gopinath, S.,Krishnamurthy, N.R.,Subramanya, H.S.,Ramachandra, M. Discovery of O-(3-carbamimidoylphenyl)-l-serine amides as matriptase inhibitors using a fragment-linking approach Bioorg.Med.Chem.Lett., 25:616-620, 2015 Cited by PubMed: 25556099DOI: 10.1016/j.bmcl.2014.12.008 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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