8GTT

Cryo-EM structure of human Pannexin1 resembling Pannexin2 pore with W74R/R75Dmutations

Summary for 8GTT

Entry DOI	10.2210/pdb8gtt/pdb
EMDB information	34267
Descriptor	Pannexin-1 (1 entity in total)
Functional Keywords	pannexin1, atp release, large-pore ion channel., membrane protein
Biological source	Homo sapiens (human)
Total number of polymer chains	7
Total formula weight	343895.31
Authors	Hussain, N.,Penmatsa, A. (deposition date: 2022-09-08, release date: 2024-02-28, Last modification date: 2024-06-19)
Primary citation	Hussain, N.,Apotikar, A.,Pidathala, S.,Mukherjee, S.,Burada, A.P.,Sikdar, S.K.,Vinothkumar, K.R.,Penmatsa, A. Cryo-EM structures of pannexin 1 and 3 reveal differences among pannexin isoforms. Nat Commun, 15:2942-2942, 2024 Cited by PubMed: 38580658 DOI: 10.1038/s41467-024-47142-6 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.2 Å)

Structure validation