4JZ1
Crystal Structure of Matriptase in complex with Inhibitor
Summary for 4JZ1
Entry DOI | 10.2210/pdb4jz1/pdb |
Related | 4JYT 4JZI |
Descriptor | Suppressor of tumorigenicity 14 protein, 4,4'-[(3-{[(4-fluorophenyl)sulfonyl]amino}pyridine-2,6-diyl)bis(oxy)]dibenzenecarboximidamide (3 entities in total) |
Functional Keywords | matriptase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Membrane ; Single-pass type II membrane protein : Q9Y5Y6 |
Total number of polymer chains | 1 |
Total formula weight | 26984.29 |
Authors | Subramanya, H.S.,Ravi, B.C.,Ashok, K.N.,Chakshusmathi, G.,Ramesh, K.S. (deposition date: 2013-04-02, release date: 2014-02-26, Last modification date: 2023-11-08) |
Primary citation | Goswami, R.,Mukherjee, S.,Wohlfahrt, G.,Ghadiyaram, C.,Nagaraj, J.,Chandra, B.R.,Sistla, R.K.,Satyam, L.K.,Samiulla, D.S.,Moilanen, A.,Subramanya, H.S.,Ramachandra, M. Discovery of Pyridyl Bis(oxy)dibenzimidamide Derivatives as Selective Matriptase Inhibitors ACS MED.CHEM.LETT., 4:1152-1157, 2013 Cited by PubMed: 24900621DOI: 10.1021/ml400213v PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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