4JZ1

Crystal Structure of Matriptase in complex with Inhibitor

Summary for 4JZ1

Entry DOI	10.2210/pdb4jz1/pdb
Related	4JYT 4JZI
Descriptor	Suppressor of tumorigenicity 14 protein, 4,4'-[(3-{[(4-fluorophenyl)sulfonyl]amino}pyridine-2,6-diyl)bis(oxy)]dibenzenecarboximidamide (3 entities in total)
Functional Keywords	matriptase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Homo sapiens (human)
Cellular location	Membrane ; Single-pass type II membrane protein : Q9Y5Y6
Total number of polymer chains	1
Total formula weight	26984.29
Authors	Subramanya, H.S.,Ravi, B.C.,Ashok, K.N.,Chakshusmathi, G.,Ramesh, K.S. (deposition date: 2013-04-02, release date: 2014-02-26, Last modification date: 2023-11-08)
Primary citation	Goswami, R.,Mukherjee, S.,Wohlfahrt, G.,Ghadiyaram, C.,Nagaraj, J.,Chandra, B.R.,Sistla, R.K.,Satyam, L.K.,Samiulla, D.S.,Moilanen, A.,Subramanya, H.S.,Ramachandra, M. Discovery of Pyridyl Bis(oxy)dibenzimidamide Derivatives as Selective Matriptase Inhibitors ACS MED.CHEM.LETT., 4:1152-1157, 2013 Cited by PubMed: 24900621 DOI: 10.1021/ml400213v PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation