8DRE

LRRC8A:C conformation 2 (oblong)

Summary for 8DRE

Entry DOI	10.2210/pdb8dre/pdb
Related	8DR8 8DRA
EMDB information	27674 27675 27676
Descriptor	Volume-regulated anion channel subunit LRRC8A,Soluble cytochrome b562, Volume-regulated anion channel subunit LRRC8C, 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, ... (4 entities in total)
Functional Keywords	ion channel, volume-regulation, membrane protein
Biological source	Mus musculus (house mouse) More
Total number of polymer chains	6
Total formula weight	636155.78
Authors	Kern, D.M.,Brohawn, S.G. (deposition date: 2022-07-20, release date: 2023-03-08, Last modification date: 2023-07-05)
Primary citation	Kern, D.M.,Bleier, J.,Mukherjee, S.,Hill, J.M.,Kossiakoff, A.A.,Isacoff, E.Y.,Brohawn, S.G. Structural basis for assembly and lipid-mediated gating of LRRC8A:C volume-regulated anion channels. Nat.Struct.Mol.Biol., 30:841-852, 2023 Cited by PubMed: 36928458 DOI: 10.1038/s41594-023-00944-6 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.18 Å)

Structure validation