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2OPN

Human Farnesyl Diphosphate Synthase Complexed with Bisphosphonate BPH-527

Summary for 2OPN
Entry DOI10.2210/pdb2opn/pdb
Related1YV5 2OPM
DescriptorFarnesyl pyrophosphate synthetase (FPP synthetase) (FPS) (Farnesyl diphosphate synthetase) [Includes: Dimethylallyltranstransferase (EC 2.5.1.1); Geranyltranstransferase (EC 2.5.1.10)], MAGNESIUM ION, PHOSPHATE ION, ... (5 entities in total)
Functional Keywordsprotein-bisphosphonate complex, transferase
Biological sourceHomo sapiens (human)
Cellular locationCytoplasm: P14324
Total number of polymer chains1
Total formula weight43544.80
Authors
Cao, R.,Gao, Y.G.,Robinson, H.,Goddard, A.,Oldfield, E. (deposition date: 2007-01-29, release date: 2007-10-02, Last modification date: 2023-08-30)
Primary citationZhang, Y.,Cao, R.,Leon, A.,Guo, R.T.,Krysiak, K.,Yin, F.,Hudock, M.P.,Mukherjee, S.,Gao, Y.G.,Robinson, H.,Song, Y.,No, J.H.,Hong, W.,Morita, C.,Wang, A.H.-J.,Oldfield, E.
Bisphosphonates: Teaching Old Drugs with New Tricks
To be Published,
Experimental method
X-RAY DIFFRACTION (2.7 Å)
Structure validation

217705

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