2OPN

Human Farnesyl Diphosphate Synthase Complexed with Bisphosphonate BPH-527

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Farnesyl pyrophosphate synthetase (FPP synthetase) (FPS) (Farnesyl diphosphate synthetase) [Includes: Dimethylallyltranstransferase (EC 2.5.1.1); Geranyltranstransferase (EC 2.5.1.10)]	polymer	374	43013.8	1	UniProt (P14324) Pfam (PF00348)	Homo sapiens (human)
2	B, C, D (A)	MAGNESIUM ION	non-polymer		24.3	3	Chemie (MG)
3	E, F (A)	PHOSPHATE ION	non-polymer		95.0	2	Chemie (PO4)
4	G (A)	[2-(DIMETHYL-LAMBDA~4~-SULFANYL)-1-HYDROXYETHANE-1,1-DIYL]BIS(PHOSPHONIC ACID)	non-polymer		268.2	1	Chemie (SUF)
5	H (A)	water	water		18.0	98	Chemie (HOH)

Sequence modifications

A: 15 - 367 (UniProt: P14324)

PDB	External Database	Details
Gly -6	-	expression tag
Ser -5	-	expression tag
Ser -4	-	expression tag
His -3	-	expression tag
His -2	-	expression tag
His -1	-	expression tag
His 0	-	expression tag
His 1	-	expression tag
His 2	-	expression tag
Ser 3	-	expression tag
Ser 4	-	expression tag
Gly 5	-	expression tag
Arg 6	-	expression tag
Glu 7	-	expression tag
Asn 8	-	expression tag
Leu 9	-	expression tag
Tyr 10	-	expression tag
Phe 11	-	expression tag
Gln 12	-	expression tag
Gly 13	-	expression tag
His 14	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	43013.8
Non-Polymers*	Number of molecules	6
	Total formula weight	531.0
All*	Total formula weight	43544.8

*Water molecules are not included.