4JYT

Crystal Structure of Matriptase in complex with Inhibitor

Summary for 4JYT

• Entry DOI: 10.2210/pdb4jyt/pdb
• Related: 4jz1 4jzi
• Descriptor: Suppressor of tumorigenicity 14 protein, 4,4'-[{3-[(naphthalen-2-ylsulfonyl)amino]pyridine-2,6-diyl}bis(oxy)]dibenzenecarboximidamide (3 entities in total)
• Functional Keywords: matriptase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Homo sapiens (human)
• Cellular location: Membrane ; Single-pass type II membrane protein : Q9Y5Y6
• Total number of polymer chains: 1
• Total formula weight: 27016.36

Authors

Subramanya, H.S.,Ravi, B.C.,Ashok, K.N.,Chakshusmathi, G.,Ramesh, K.S. (deposition date: 2013-04-01, release date: 2014-03-19, Last modification date: 2023-11-08)

• Primary citation: Goswami, R.,Mukherjee, S.,Wohlfahrt, G.,Ghadiyaram, C.,Nagaraj, J.,Chandra, B.R.,Sistla, R.K.,Satyam, L.K.,Samiulla, D.S.,Moilanen, A.,Subramanya, H.S.,Ramachandra, M.; Discovery of Pyridyl Bis(oxy)dibenzimidamide Derivatives as Selective Matriptase Inhibitors; ACS MED.CHEM.LETT., 4:1152-1157, 2013; PubMed: 24900621; DOI: 10.1021/ml400213v

Experimental method

X-RAY DIFFRACTION (2 Å)