1U7V
 
 | | Crystal Structure of the phosphorylated Smad2/Smad4 heterotrimeric complex | | Descriptor: | Mothers against decapentaplegic homolog 2, Mothers against decapentaplegic homolog 4 | | Authors: | Chacko, B.M, Qin, B.Y, Tiwari, A, Shi, G, Lam, S, Hayward, L.J, de Caestecker, M, Lin, K. | | Deposit date: | 2004-08-04 | | Release date: | 2004-09-28 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Structural basis of heteromeric smad protein assembly in tgf-Beta signaling
Mol.Cell, 15, 2004
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1U7F
 | | Crystal Structure of the phosphorylated Smad3/Smad4 heterotrimeric complex | | Descriptor: | Mothers against decapentaplegic homolog 3, Mothers against decapentaplegic homolog 4 | | Authors: | Chacko, B.M, Qin, B.Y, Tiwari, A, Shi, G, Lam, S, Hayward, L.J, de Caestecker, M, Lin, K. | | Deposit date: | 2004-08-03 | | Release date: | 2004-09-28 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Structural basis of heteromeric smad protein assembly in tgf-Beta signaling
Mol.Cell, 15, 2004
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3VAX
 | | Crystal structure of DndA from streptomyces lividans | | Descriptor: | PYRIDOXAL-5'-PHOSPHATE, Putative uncharacterized protein dndA | | Authors: | Zhang, Z, Chen, F, Lin, K, Wu, G. | | Deposit date: | 2011-12-30 | | Release date: | 2013-01-02 | | Last modified: | 2024-03-20 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Crystal structure of the cysteine desulfurase DndA from Streptomyces lividans which is involved in DNA phosphorothioation
Plos One, 7, 2012
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3DSH
 | | Crystal structure of dimeric interferon regulatory factor 5 (IRF-5) transactivation domain | | Descriptor: | Interferon regulatory factor 5 | | Authors: | Chen, W, Lam, S.S, Srinath, H, Jiang, Z, Correia, J.J, Schiffer, C, Fitzgerald, K.A, Lin, K, Royer Jr, W.E. | | Deposit date: | 2008-07-12 | | Release date: | 2008-10-07 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Insights into interferon regulatory factor activation from the crystal structure of dimeric IRF5.
Nat.Struct.Mol.Biol., 15, 2008
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7ED5
 | | A dual mechanism of action of AT-527 against SARS-CoV-2 polymerase | | Descriptor: | MAGNESIUM ION, Non-structural protein 7, Non-structural protein 8, ... | | Authors: | Shannon, A, Fattorini, V, Sama, B, Selisko, B, Feracci, M, Falcou, C, Gauffre, P, El Kazzi, P, Delpal, A, Decroly, E, Alvarez, K, Eydoux, C, Guillemot, J.-C, Moussa, A, Good, S, Colla, P, Lin, K, Sommadossi, J.-P, Zhu, Y.X, Yan, X.D, Shi, H, Ferron, F, Canard, B. | | Deposit date: | 2021-03-15 | | Release date: | 2022-02-16 | | Last modified: | 2024-04-10 | | Method: | ELECTRON MICROSCOPY (2.98 Å) | | Cite: | A dual mechanism of action of AT-527 against SARS-CoV-2 polymerase.
Nat Commun, 13, 2022
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1KHU
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8UW3
 | | Human LINE-1 retrotransposon ORF2 protein engaged with template RNA in elongation state | | Descriptor: | Complementary DNA, LINE-1 retrotransposable element ORF2 protein, THYMIDINE-5'-TRIPHOSPHATE, ... | | Authors: | Thawani, A, Florez Ariza, A.J, Collins, K, Nogales, E. | | Deposit date: | 2023-11-06 | | Release date: | 2023-12-20 | | Last modified: | 2024-02-14 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | Template and target-site recognition by human LINE-1 in retrotransposition.
Nature, 626, 2024
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1DD1
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1MK2
 | | SMAD3 SBD complex | | Descriptor: | ACETIC ACID, Madh-interacting protein, SMAD 3 | | Authors: | Qin, B.Y, Lam, S.S, Correia, J.J, Lin, K. | | Deposit date: | 2002-08-28 | | Release date: | 2002-10-16 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (2.74 Å) | | Cite: | Smad3 allostery links TGF-beta receptor kinase activation to transcriptional control
Genes Dev., 16, 2002
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1G88
 | | S4AFL3ARG515 MUTANT | | Descriptor: | SMAD4 | | Authors: | Chako, B.M, Qin, B, Lam, S.S, Correia, J.J, Lin, K. | | Deposit date: | 2000-11-16 | | Release date: | 2000-11-29 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | The L3 loop and C-terminal phosphorylation jointly define Smad protein trimerization.
Nat.Struct.Biol., 8, 2001
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8FX1
 | | Crystal structure of the Trypanosoma cruzi hypoxanthine-guanine-xanthine phosphoribosyltransferase (HGXPRT), isoform D, bound to (R)-SerMe-ImmH Phosphonate | | Descriptor: | Hypoxanthine-guanine phosphoribosyltransferase, [(3R)-4-hydroxy-3-{[(4-oxo-4,5-dihydro-3H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]amino}butyl]phosphonic acid | | Authors: | Hughes, R, Meneely, K.M, Glockzin, K, Clinch, K, Tyler, P.C, Lamb, A.L, Meek, T.D, Katzfuss, A. | | Deposit date: | 2023-01-23 | | Release date: | 2023-07-19 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Kinetic and Structural Characterization of Trypanosoma cruzi Hypoxanthine-Guanine-Xanthine Phosphoribosyltransferases and Repurposing of Transition-State Analogue Inhibitors.
Biochemistry, 62, 2023
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8FX0
 | | Crystal structure of the Trypanosoma cruzi hypoxanthine-guanine-xanthine phosphoribosyltransferase (HGXPRT), isoform D, bound to (S)-SerMe-ImmH Phosphonate | | Descriptor: | Hypoxanthine-guanine phosphoribosyltransferase, [(3R)-4-hydroxy-3-{[(4-oxo-4,5-dihydro-3H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]amino}butyl]phosphonic acid | | Authors: | Hughes, R, Meneely, K.M, Glockzin, K, Clinch, K, Tyler, P.C, Lamb, A.L, Meek, T.D, Katzfuss, A. | | Deposit date: | 2023-01-23 | | Release date: | 2023-07-19 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (1.52 Å) | | Cite: | Kinetic and Structural Characterization of Trypanosoma cruzi Hypoxanthine-Guanine-Xanthine Phosphoribosyltransferases and Repurposing of Transition-State Analogue Inhibitors.
Biochemistry, 62, 2023
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8FWZ
 | | Crystal structure of the Trypanosoma cruzi hypoxanthine-guanine-xanthine phosphoribosyltransferase (HGXPRT), isoform D, bound to Hydroxypropyl-Lin-ImmH Phosphonate | | Descriptor: | Hypoxanthine-guanine phosphoribosyltransferase, PHOSPHATE ION, [(2R)-2-hydroxy-3-{[(4-oxo-4,5-dihydro-3H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]amino}propyl]phosphonic acid | | Authors: | Hughes, R, Meneely, K.M, Glockzin, K, Clinch, K, Tyler, P.C, Lamb, A.L, Meek, T.D, Katzfuss, A. | | Deposit date: | 2023-01-23 | | Release date: | 2023-07-19 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (1.65 Å) | | Cite: | Kinetic and Structural Characterization of Trypanosoma cruzi Hypoxanthine-Guanine-Xanthine Phosphoribosyltransferases and Repurposing of Transition-State Analogue Inhibitors.
Biochemistry, 62, 2023
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7BGB
 | | The H/ACA RNP lobe of human telomerase | | Descriptor: | H/ACA ribonucleoprotein complex subunit 1, H/ACA ribonucleoprotein complex subunit 2, H/ACA ribonucleoprotein complex subunit 3, ... | | Authors: | Nguyen, T.H.D, Ghanim, G.E, Fountain, A.J, van Roon, A.M.M, Rangan, R, Das, R, Collins, K. | | Deposit date: | 2021-01-06 | | Release date: | 2021-04-28 | | Last modified: | 2024-05-01 | | Method: | ELECTRON MICROSCOPY (3.4 Å) | | Cite: | Structure of human telomerase holoenzyme with bound telomeric DNA.
Nature, 593, 2021
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7BG9
 | | The catalytic core lobe of human telomerase in complex with a telomeric DNA substrate | | Descriptor: | DNA (5'-D(P*TP*TP*AP*GP*GP*G)-3'), Histone H2A, Histone H2B, ... | | Authors: | Nguyen, T.H.D, Ghanim, G.E, Fountain, A.J, van Roon, A.M.M, Rangan, R, Das, R, Collins, K. | | Deposit date: | 2021-01-06 | | Release date: | 2021-04-28 | | Last modified: | 2024-05-01 | | Method: | ELECTRON MICROSCOPY (3.8 Å) | | Cite: | Structure of human telomerase holoenzyme with bound telomeric DNA.
Nature, 593, 2021
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6ZAK
 | | Room temperature XFEL Isopenicillin N synthase structure in complex with the Fe(IV)=O mimic VO and ACV. | | Descriptor: | Isopenicillin N synthase, L-D-(A-AMINOADIPOYL)-L-CYSTEINYL-D-VALINE, SULFATE ION, ... | | Authors: | Rabe, P, Kamps, J.J.A.G, Sutherlin, K, Pharm, C, McDonough, M.A, Leissing, T.M, Aller, P, Butryn, A, Linyard, J, Lang, P, Brem, J, Fuller, F.D, Batyuk, A, Hunter, M.S, Pettinati, I, Clifton, I.J, Alonso-Mori, R, Gul, S, Young, I, Kim, I, Bhowmick, A, ORiordan, L, Brewster, A.S, Claridge, T.D.W, Sauter, N.K, Yachandra, V, Yano, J, Kern, J.F, Orville, A.M, Schofield, C.J. | | Deposit date: | 2020-06-05 | | Release date: | 2022-01-12 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (1.54 Å) | | Cite: | Room temperature XFEL Isopenicillin N synthase structure in complex with the Fe(IV)=O mimic VO and ACV.
To Be Published
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8DTN
 | | The complex of nanobody 6101 with BCL11A ZF6 | | Descriptor: | B-cell lymphoma/leukemia 11A, MAGNESIUM ION, Nanobody 6101, ... | | Authors: | Yin, M, Tenglin, K, Zhai, L, Dassama, L.M, Orkin, S.H. | | Deposit date: | 2022-07-26 | | Release date: | 2023-02-01 | | Method: | X-RAY DIFFRACTION (2.199 Å) | | Cite: | Evolution of nanobodies specific for BCL11A.
Proc.Natl.Acad.Sci.USA, 120, 2023
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8DTU
 | | The complex of nanobody 5344N74D with BCL11A ZF6. | | Descriptor: | B-cell lymphoma/leukemia 11A, Nanobody 5344N74D, ZINC ION | | Authors: | Yin, M, Tenglin, K, Zhai, L, Dassama, L.M, Orkin, S.H. | | Deposit date: | 2022-07-26 | | Release date: | 2023-02-01 | | Method: | X-RAY DIFFRACTION (2.447 Å) | | Cite: | Evolution of nanobodies specific for BCL11A.
Proc.Natl.Acad.Sci.USA, 120, 2023
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5NDA
 | | NMR Structural Characterisation of Pharmaceutically Relevant Proteins Obtained Through a Novel Recombinant Production: The Case of The Pulmonary Surfactant Polypeptide C Analogue rSP-C33Leu. | | Descriptor: | rSP-C33Leu -RECOMBINANT PULMONARY SURFACTANT-ASSOCIATED POLYPEPTIDE C ANALOGUE- | | Authors: | Venturi, L, Pioselli, B, Johansson, J, Rising, A, Kronqvist, N, Nordling, K. | | Deposit date: | 2017-03-08 | | Release date: | 2017-06-07 | | Last modified: | 2024-06-19 | | Method: | SOLUTION NMR | | Cite: | Efficient protein production inspired by how spiders make silk.
Nat Commun, 8, 2017
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3LR2
 | | Self-assembly of spider silk proteins is controlled by a pH-sensitive relay | | Descriptor: | 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, Major ampullate spidroin 1 | | Authors: | Askarieh, G, Hedhammar, H, Nordling, K, Johansson, J, Knight, S.D, Rising, A, Casals, C, Saenz, A. | | Deposit date: | 2010-02-10 | | Release date: | 2010-05-12 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Self-assembly of spider silk proteins is controlled by a pH-sensitive relay.
Nature, 465, 2010
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3LR6
 | | Self-assembly of spider silk proteins is controlled by a pH-sensitive relay | | Descriptor: | Major ampullate spidroin 1, TRIETHYLENE GLYCOL | | Authors: | Askarieh, G, Hedhammar, H, Nordling, K, Saenz, A, Casals, C, Rising, A, Johansson, J, Knight, S.D. | | Deposit date: | 2010-02-10 | | Release date: | 2010-05-12 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Self-assembly of spider silk proteins is controlled by a pH-sensitive relay.
Nature, 465, 2010
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3LR8
 | | Self-assembly of spider silk proteins is controlled by a pH-sensitive relay | | Descriptor: | 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, Major ampullate spidroin 1, ... | | Authors: | Askarieh, G, Hedhammar, H, Nordling, K, Rising, A, Johansson, J, Knight, S.D. | | Deposit date: | 2010-02-10 | | Release date: | 2010-05-12 | | Last modified: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Self-assembly of spider silk proteins is controlled by a pH-sensitive relay.
Nature, 465, 2010
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3LRD
 | | Self-assembly of spider silk proteins is controlled by a pH-sensitive relay | | Descriptor: | 1,2-ETHANEDIOL, Major ampullate spidroin 1, TRIETHYLENE GLYCOL | | Authors: | Askarieh, G, Hedhammar, H, Nordling, K, Rising, A, Johansson, J, Knight, S.D, Saenz, A, Casals, C. | | Deposit date: | 2010-02-11 | | Release date: | 2010-05-12 | | Last modified: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (2.15 Å) | | Cite: | Self-assembly of spider silk proteins is controlled by a pH-sensitive relay.
Nature, 465, 2010
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8SH4
 | | Crystal structure of the tRNA (m1G37) methyltransferase apoenzyme from Anaplasma phagocytophilum | | Descriptor: | GLYCEROL, tRNA (guanine-N(1)-)-methyltransferase | | Authors: | Jannotta, C, Edele, D, Levanti, D, Carson, M, Prucha, G, Caesar, J, Picchiello, C, Collins, K, Garland, E, Handley-Pendleton, J, Hernandez, V, Leffler, S, Williams, D, Stojanoff, V, Perez, A, Halloran, J, Bolen, R. | | Deposit date: | 2023-04-13 | | Release date: | 2024-04-17 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | Crystal structure of the m1G37 tRNA methyltransferase apoenzyme from Anaplasma phagocytophilum
To Be Published
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8BSG
 | | COMPLEX OF LEPORINE SERUM ALBUMIN WITH DICLOFENAC | | Descriptor: | (20S)-2,5,8,11,14,17-HEXAMETHYL-3,6,9,12,15,18-HEXAOXAHENICOSANE-1,20-DIOL, 2-[2,6-DICHLOROPHENYL)AMINO]BENZENEACETIC ACID, ACETATE ION, ... | | Authors: | Bujacz, A, Talaj, J, Zielinski, K. | | Deposit date: | 2022-11-25 | | Release date: | 2023-02-08 | | Last modified: | 2024-10-09 | | Method: | X-RAY DIFFRACTION (1.89 Å) | | Cite: | Structural Investigation of Diclofenac Binding to Ovine, Caprine, and Leporine Serum Albumins.
Int J Mol Sci, 24, 2023
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