7ED5
A dual mechanism of action of AT-527 against SARS-CoV-2 polymerase
Summary for 7ED5
Entry DOI | 10.2210/pdb7ed5/pdb |
EMDB information | 31061 |
Descriptor | RNA-directed RNA polymerase, Non-structural protein 8, Non-structural protein 7, ... (8 entities in total) |
Functional Keywords | sars-cov-2, nsp12, niran, rdrp, at-9010, at-527, viral protein |
Biological source | Severe acute respiratory syndrome coronavirus 2 More |
Total number of polymer chains | 6 |
Total formula weight | 189253.30 |
Authors | Shannon, A.,Fattorini, V.,Sama, B.,Selisko, B.,Feracci, M.,Falcou, C.,Gauffre, P.,El Kazzi, P.,Delpal, A.,Decroly, E.,Alvarez, K.,Eydoux, C.,Guillemot, J.-C.,Moussa, A.,Good, S.,Colla, P.,Lin, K.,Sommadossi, J.-P.,Zhu, Y.X.,Yan, X.D.,Shi, H.,Ferron, F.,Canard, B. (deposition date: 2021-03-15, release date: 2022-02-16, Last modification date: 2024-04-10) |
Primary citation | Shannon, A.,Fattorini, V.,Sama, B.,Selisko, B.,Feracci, M.,Falcou, C.,Gauffre, P.,El Kazzi, P.,Delpal, A.,Decroly, E.,Alvarez, K.,Eydoux, C.,Guillemot, J.C.,Moussa, A.,Good, S.S.,La Colla, P.,Lin, K.,Sommadossi, J.P.,Zhu, Y.,Yan, X.,Shi, H.,Ferron, F.,Canard, B. A dual mechanism of action of AT-527 against SARS-CoV-2 polymerase. Nat Commun, 13:621-621, 2022 Cited by PubMed: 35110538DOI: 10.1038/s41467-022-28113-1 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (2.98 Å) |
Structure validation
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