7ED5

A dual mechanism of action of AT-527 against SARS-CoV-2 polymerase

Summary for 7ED5

• Entry DOI: 10.2210/pdb7ed5/pdb
• EMDB information: 31061
• Descriptor: RNA-directed RNA polymerase, Non-structural protein 8, Non-structural protein 7, ... (8 entities in total)
• Functional Keywords: sars-cov-2, nsp12, niran, rdrp, at-9010, at-527, viral protein
• Biological source: Severe acute respiratory syndrome coronavirus 2; More
• Total number of polymer chains: 6
• Total formula weight: 189253.30

Authors

Shannon, A.,Fattorini, V.,Sama, B.,Selisko, B.,Feracci, M.,Falcou, C.,Gauffre, P.,El Kazzi, P.,Delpal, A.,Decroly, E.,Alvarez, K.,Eydoux, C.,Guillemot, J.-C.,Moussa, A.,Good, S.,Colla, P.,Lin, K.,Sommadossi, J.-P.,Zhu, Y.X.,Yan, X.D.,Shi, H.,Ferron, F.,Canard, B. (deposition date: 2021-03-15, release date: 2022-02-16, Last modification date: 2024-04-10)

• Primary citation: Shannon, A.,Fattorini, V.,Sama, B.,Selisko, B.,Feracci, M.,Falcou, C.,Gauffre, P.,El Kazzi, P.,Delpal, A.,Decroly, E.,Alvarez, K.,Eydoux, C.,Guillemot, J.C.,Moussa, A.,Good, S.S.,La Colla, P.,Lin, K.,Sommadossi, J.P.,Zhu, Y.,Yan, X.,Shi, H.,Ferron, F.,Canard, B.; A dual mechanism of action of AT-527 against SARS-CoV-2 polymerase.; Nat Commun, 13:621-621, 2022; PubMed: 35110538; DOI: 10.1038/s41467-022-28113-1

Experimental method

ELECTRON MICROSCOPY (2.98 Å)