Crystal Structure of the phosphorylated Smad3/Smad4 heterotrimeric complex

Summary for 1U7F

DescriptorMothers against decapentaplegic homolog 3, Mothers against decapentaplegic homolog 4 (3 entities in total)
Functional Keywordssmad, tgf-beta, signal transduction, protein complex, phosphorylation, signaling protein
Biological sourceHomo sapiens (human)
Cellular locationCytoplasm P84022 Q13485
Total number of polymer chains3
Total molecular weight70995.24
Chacko, B.M.,Qin, B.Y.,Tiwari, A.,Shi, G.,Lam, S.,Hayward, L.J.,de Caestecker, M.,Lin, K. (deposition date: 2004-08-03, release date: 2004-09-28, Last modification date: 2011-07-13)
Primary citation
Chacko, B.M.,Qin, B.Y.,Tiwari, A.,Shi, G.,Lam, S.,Hayward, L.J.,De Caestecker, M.,Lin, K.
Structural basis of heteromeric smad protein assembly in tgf-Beta signaling
Mol.Cell, 15:813-823, 2004
PubMed: 15350224 (PDB entries with the same primary citation)
DOI: 10.1016/j.molcel.2004.07.016
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.244363.7%7.1%5.0%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation reportDownload
PDB entries from 2020-09-16