1U7F

Crystal Structure of the phosphorylated Smad3/Smad4 heterotrimeric complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0006355	biological_process	regulation of DNA-templated transcription
B	0006355	biological_process	regulation of DNA-templated transcription
C	0006355	biological_process	regulation of DNA-templated transcription

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	106
Details	Region: {"description":"Sufficient for interaction with XPO4","evidences":[{"source":"PubMed","id":"16449645","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	2
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"16862174","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine; by CK1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00439","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"18794808","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI5
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine; by TGFBR1","evidences":[{"source":"UniProtKB","id":"Q8BUN5","evidenceCode":"ECO:0000250"},{"source":"PROSITE-ProRule","id":"PRU00439","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI6
Number of Residues	1
Details	Site: {"description":"Necessary for heterotrimerization"}

Chain

Residue

Details

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site_id	SWS_FT_FI7
Number of Residues	2
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI8
Number of Residues	2
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"19135894","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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