3DSH

Crystal structure of dimeric interferon regulatory factor 5 (IRF-5) transactivation domain

Summary for 3DSH

Entry DOI	10.2210/pdb3dsh/pdb
Descriptor	Interferon regulatory factor 5 (2 entities in total)
Functional Keywords	phosphoactivation induced dimerization, dna-binding, nucleus, transcription, transcription regulation, dna binding protein
Biological source	Homo sapiens (Human)
Cellular location	Nucleus: Q13568
Total number of polymer chains	1
Total formula weight	28595.84
Authors	Chen, W.,Lam, S.S.,Srinath, H.,Jiang, Z.,Correia, J.J.,Schiffer, C.,Fitzgerald, K.A.,Lin, K.,Royer Jr., W.E. (deposition date: 2008-07-12, release date: 2008-10-07, Last modification date: 2024-02-21)
Primary citation	Chen, W.,Lam, S.S.,Srinath, H.,Jiang, Z.,Correia, J.J.,Schiffer, C.A.,Fitzgerald, K.A.,Lin, K.,Royer, W.E. Insights into interferon regulatory factor activation from the crystal structure of dimeric IRF5. Nat.Struct.Mol.Biol., 15:1213-1220, 2008 Cited by PubMed: 18836453 DOI: 10.1038/nsmb.1496 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation