4EHP

Crystal Structure of human vinculin head domain (residues 1-252) in complex with alpha-catenin (residues 277-382)

Summary for 4EHP

Related1tr2 1rke 4dj9 3tj5 1syq 1rkc 2gww 3rf3 3s90 3tj6 2hsq 2ibf 1ydi 3h2u 3h2v 3myi 3smz
DescriptorVinculin, Catenin alpha-1, ACETATE ION, ... (4 entities in total)
Functional Keywordsadherens junctions, vinculin binding site, vinculin binding domain, helix bundle, cell adhesion
Biological sourceHomo sapiens (human)
Cellular locationCytoplasm, cytoskeleton P18206 P35221
Total number of polymer chains2
Total molecular weight41349.35
Authors
Izard, T.,Rangarajan, E.S. (deposition date: 2012-04-03, release date: 2012-04-18, Last modification date: 2013-07-17)
Primary citation
Rangarajan, E.S.,Izard, T.
alpha-Catenin unfurls upon binding to vinculin
J.Biol.Chem., 287:18492-18499, 2012
PubMed: 22493458 (PDB entries with the same primary citation)
DOI: 10.1074/jbc.M112.351023
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.66 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.233401.7%3.5%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 4ehp
no rotation
Molmil generated image of 4ehp
rotated about x axis by 90°
Molmil generated image of 4ehp
rotated about y axis by 90°
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