Human vinculin head domain VH1, residues 1-258, in complex with human talin's vinculin binding site 1, residues 607-636

Summary for 1SYQ

Descriptorvinculin isoform VCL, Talin 1 (3 entities in total)
Functional Keywordscytoskeleton, vinculin, talin, cell adhesion
Biological sourceHomo sapiens (human)
Cellular locationCytoplasm, cytoskeleton P18206
Cell projection, ruffle membrane; Peripheral membrane protein; Cytoplasmic side (By similarity) Q9Y490
Total number of polymer chains2
Total molecular weight32188.07
Izard, T.,Vonrhein, C. (deposition date: 2004-04-01, release date: 2004-07-20, Last modification date: 2011-07-13)
Primary citation
Izard, T.,Vonrhein, C.
Structural basis for amplifying vinculin activation by talin
J.Biol.Chem., 279:27667-27678, 2004
PubMed: 15070891 (PDB entries with the same primary citation)
DOI: 10.1074/jbc.M403076200
MImport into Mendeley
Experimental method

Structure validation

ClashscoreRamachandran outliersSidechain outliers210.4%11.8%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 1syq
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Molmil generated image of 1syq
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Molmil generated image of 1syq
rotated about y axis by 90°
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