3TJ6

human vinculin head domain (Vh1, residues 1-258) in complex with the vinculin binding site of the surface cell antigen 4 (sca4-VBS-C; residues 812-835) from Rickettsia rickettsii

Summary for 3TJ6

Related3rf3 2ibf 2hsq 2gww 1rkc 3s90 3TJ5
DescriptorVinculin, Antigenic heat-stable 120 kDa protein (3 entities in total)
Functional Keywordscytoskeleton, epidemic typhus, sca4, spotted fever, alpha-helix bundle domain, protein-protein interactions, cell adhesion, cytosol, focal adhesion, protein binding-toxin complex, protein binding/toxin
Biological sourceHomo sapiens (human)
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Cellular locationCell membrane ; Peripheral membrane protein ; Cytoplasmic side  P18206
Total number of polymer chains2
Total molecular weight31368.13
Authors
Park, H.,Lee, J.H.,Gouin, E.,Cossart, P.,Izard, T. (deposition date: 2011-08-23, release date: 2011-09-07, Last modification date: 2017-11-08)
Primary citation
Park, H.,Lee, J.H.,Gouin, E.,Cossart, P.,Izard, T.
The rickettsia surface cell antigen 4 applies mimicry to bind to and activate vinculin.
J.Biol.Chem., 286:35096-35103, 2011
PubMed: 21841197 (PDB entries with the same primary citation)
DOI: 10.1074/jbc.M111.263855
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.76 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.22930.4%3.7%8.0%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 3tj6
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Molmil generated image of 3tj6
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Molmil generated image of 3tj6
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More Biological unit images

Molmil generated image of 3tj6
no rotation
Molmil generated image of 3tj6
rotated about x axis by 90°
Molmil generated image of 3tj6
rotated about y axis by 90°
(*)In the case of coarse surface representation, the asymmetric unit is shown as red ribbon representation.
Coordinate files for Biological unit (3tj6.pdb1.gz [94.48 KB])
Coordinate files for Biological unit (3tj6.pdb2.gz [279.77 KB])
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