2HSQ

Human vinculin (head domain, Vh1, residues 1-258) in complex with Shigella's IpaA vinculin binding site 2 (residues 565-587)

Summary for 2HSQ

Related2GWW
DescriptorVinculin, Invasin ipaA (2 entities in total)
Functional Keywordsprotein complex, cell adhesion, structural protein
Biological sourceHomo sapiens (human)
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Cellular locationCytoplasm, cytoskeleton P18206
Secreted P18010
Total number of polymer chains2
Total molecular weight32526.44
Authors
Izard, T. (deposition date: 2006-07-22, release date: 2006-11-21, Last modification date: 2011-07-13)
Primary citation
Izard, T.,Tran Van Nhieu, G.,Bois, P.R.
Shigella applies molecular mimicry to subvert vinculin and invade host cells.
J.Cell Biol., 175:465-475, 2006
PubMed: 17088427 (PDB entries with the same primary citation)
DOI: 10.1083/jcb.200605091
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (3.97 Å)
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Structure validation

ClashscoreRamachandran outliersSidechain outliers703.2%42.5%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 2hsq
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Molmil generated image of 2hsq
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Molmil generated image of 2hsq
rotated about y axis by 90°
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