Human vinculin head domain Vh1 (residues 1-258) in complex with the talin vinculin binding site 50 (VBS50, residues 2078-2099)

Summary for 4DJ9

Related1rkc 1syq 3s90 3tj5 3tj6 1rke
DescriptorVinculin, Talin-1 (3 entities in total)
Functional Keywordscytoskeleton, focal adhesion, protein-protein interaction, four-helix bundle, cell adhesion, f-actin, cytosol
Biological sourceHomo sapiens (human)
Cellular locationCytoplasm, cytoskeleton P18206
Cell projection, ruffle membrane; Peripheral membrane protein; Cytoplasmic side (By similarity) Q9Y490
Total number of polymer chains2
Total molecular weight31807.72
Yogesha, S.D.,Rangarajan, E.S.,Vonrhein, C.,Bricogne, G.,Izard, T. (deposition date: 2012-02-01, release date: 2012-02-29, Last modification date: 2012-05-16)
Primary citation
Yogesha, S.D.,Rangarajan, E.S.,Vonrhein, C.,Bricogne, G.,Izard, T.
Crystal structure of vinculin in complex with vinculin binding site 50 (VBS50), the integrin binding site 2 (IBS2) of talin.
Protein Sci., 21:583-588, 2012
PubMed: 22334306 (PDB entries with the same primary citation)
DOI: 10.1002/pro.2041
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.256100.9%1.1%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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