3ZQR

NMePheB25 insulin analogue crystal structure

Summary for 3ZQR

Related1HIT 2HHO 2C8Q 2W44 1TYL 2C8R 1T1K 2WRV 1AIY 1XDA 1HTV 1MSO 1UZ9 2WS6 1FUB 1TYM 1HUI 2VK0 1VKT 1HLS 2CEU 1T1Q 1QJ0 2WS0 1MHJ 1FU2 1SJT 1QIY 1IOG 2VJZ 1IOH 1TRZ 1EVR 1SJU 1EV3 1RWE 1OS4 1GUJ 1AI0 1SF1 1JCO 1JCA 1ZEG 1OS3 1XGL 1QIZ 1T0C 1G7B 2WBY 2AIY 1EV6 1Q4V 2WS7 2HH4 2H67 4AIY 1J73 1K3M 1MHI 2WC0 1KMF 2HIU 1XW7 2WRW 5AIY 1G7A 1ZNJ 2WS4 1ZEH 1HIS 1B9E 3AIY 1W8P 2WS1 2WRX 1HIQ 1LPH 1EFE 1A7F 1T1P 1BEN 2WRU 1LKQ
DescriptorINSULIN A CHAIN, INSULIN B CHAIN, PHENOL, ... (6 entities in total)
Functional Keywordscarbohydrate metabolism, glucose metabolism, hormone, diabetes mellitus
Biological sourceHOMO SAPIENS (HUMAN)
Cellular locationSecreted P01308 P01308
Total number of polymer chains12
Total molecular weight35756.46
Authors
Antolikova, E.,Zakova, L.,Turkenburg, J.P.,Watson, C.J.,Hanclova, I.,Sanda, M.,Cooper, A.,Kraus, T.,Brzozowski, A.M.,Jiracek, J.A. (deposition date: 2011-06-10, release date: 2011-08-24, Last modification date: 2017-06-28)
Primary citation
Antolikova, E.,Zakova, L.,Turkenburg, J.P.,Watson, C.J.,Hanclova, I.,Sanda, M.,Cooper, A.,Kraus, T.,Brzozowski, A.M.,Jiracek, J.A.
Non-Equivalent Role of Inter- and Intramolecular Hydrogen Bonds in the Insulin Dimer Interface.
J.Biol.Chem., 286:36968-, 2011
PubMed: 21880708 (PDB entries with the same primary citation)
DOI: 10.1074/JBC.M111.265249
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.9 Å)
NMR Information
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.27250.4%6.4%3.5%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation report