2WRU

Semi-synthetic highly active analogue of human insulin NMeAlaB26-DTI- NH2

Summary for 2WRU
Related1A7F 1AI0 1AIY 1B9E 1BEN 1EFE 1EV3 1EV6 1EVR 1FU2 1FUB 1G7A 1G7B 1GUJ 1HIQ 1HIS 1HIT 1HLS 1HTV 1HUI 1IOG 1IOH 1J73 1JCA 1JCO 1K3M 1KMF 1LKQ 1LPH 1MHI 1MHJ 1MSO 1OS3 1OS4 1Q4V 1QIY 1QIZ 1QJ0 1RWE 1SF1 1SJT 1T0C 1T1K 1T1P 1T1Q 1TRZ 1TYL 1TYM 1UZ9 1VKT 1W8P 1XDA 1XGL 1XW7 1ZEG 1ZEH 1ZNJ 2AIY 2C8Q 2C8R 2CEU 2H67 2HH4 2HHO 2HIU 2VJZ 2VK0 2WBY 2WC0 2WRV 2WRW 2WRX 2WS0 2WS1 2WS4 2WS6 2WS7 3AIY 4AIY 5AIY
DescriptorINSULIN A CHAIN, INSULIN B CHAIN, ACETATE ION, ... (4 entities in total)
Functional Keywordscarbohydrate metabolism, glucose metabolism, hormone, analogue, diabetes mellitus
Biological sourceHOMO SAPIENS (HUMAN)
More
Cellular locationSecreted: P01308 P01308
Total number of polymer chains2
Total formula weight5428.18
Authors
Brzozowski, A.M.,Jiracek, J.,Zakova, L.,Antolikova, E.,Watson, C.J.,Turkenburg, J.P.,Dodson, G.G. (deposition date: 2009-09-02, release date: 2010-02-09, Last modification date: 2013-03-20)
Primary citationAntolikova, E.,Brzozowski, A.M.,Dodson, G.G.,Jiracek, J.,Turkenburg, J.P.,Watson, C.J.,Zakova, L.
Implications for the Active Form of Human Insulin Based on the Structural Convergence of Highly Active Hormone Analogues.
Proc.Natl.Acad.Sci.USA, 107:1966-, 2010
PubMed: 20133841
DOI: 110.1073/PNAS.0911785107
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.57 Å)
Structure validation
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PDB entries from 2021-06-16