2WS1

Semi-synthetic analogue of human insulin NMeTyrB26-insulin in monomer form

Summary for 2WS1

Related1HIT 2HHO 2C8Q 1TYL 2C8R 1T1K 1AIY 1XDA 1HTV 1MSO 1UZ9 1FUB 1TYM 1HUI 2VK0 1VKT 1HLS 2CEU 1T1Q 1QJ0 1MHJ 1FU2 1SJT 1QIY 1IOG 2VJZ 1IOH 1TRZ 1EVR 1EV3 1RWE 1OS4 1GUJ 1AI0 1SF1 1JCO 1JCA 1ZEG 1OS3 1XGL 1T0C 1QIZ 1G7B 2WBY 2AIY 1EV6 1Q4V 2HH4 2H67 4AIY 1J73 1K3M 1MHI 2WC0 1KMF 2HIU 1XW7 5AIY 1G7A 1ZNJ 1ZEH 1HIS 1B9E 3AIY 1W8P 1HIQ 1LPH 1EFE 1A7F 1T1P 1BEN 1LKQ 2WS7 2WS0 2WS4 2WS6 2WRX 2WRW 2WRU 2WRV
DescriptorINSULIN A CHAIN, INSULIN B CHAIN, ACETATE ION, ... (4 entities in total)
Functional Keywordscarbohydrate metabolism, glucose metabolism, hormone, analogue, diabetes mellitus
Biological sourceHOMO SAPIENS (HUMAN)
Cellular locationSecreted P01308 P01308
Total number of polymer chains2
Total molecular weight5890.72
Authors
Brzozowski, A.M.,Jiracek, J.,Zakova, L.,Antolikova, E.,Watson, C.J.,Turkenburg, J.P.,Dodson, G.G. (deposition date: 2009-09-03, release date: 2010-02-09, Last modification date: 2012-04-04)
Primary citation
Jiracek, J.,Zakova, L.,Antolikova, E.,Watson, C.J.,Turkenburg, J.P.,Dodson, G.G.,Brzozowski, A.M.
Implications for the Active Form of Human Insulin Based on the Structural Convergence of Highly Active Hormone Analogues.
Proc.Natl.Acad.Sci.USA, 107:1966-, 2010
PubMed: 20133841 (PDB entries with the same primary citation)
DOI: 10.1073/PNAS.0911785107
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.6 Å)
NMR Information
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.25790012.8%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution