1WBS
Identification of novel p38 alpha MAP Kinase inhibitors using fragment-based lead generation.
Summary for 1WBS
Entry DOI | 10.2210/pdb1wbs/pdb |
Related | 1A9U 1BL6 1BL7 1BMK 1DI9 1IAN 1KV1 1KV2 1M7Q 1OUK 1OUY 1OVE 1OZ1 1R39 1R3C 1W7H 1W82 1W83 1W84 1WBN 1WBO 1WBT 1WBV 1WBW 1WFC 1YQJ 1ZZ2 1ZZL |
Descriptor | MITOGEN-ACTIVATED PROTEIN KINASE 14, 3-FLUORO-5-MORPHOLIN-4-YL-N-[3-(2-PYRIDIN-4-YLETHYL)-1H-INDOL-5-YL]BENZAMIDE, GLYCEROL, ... (4 entities in total) |
Functional Keywords | p38, map kinase, inhibitor structure, alternative splicing, atp-binding, nuclear protein, phosphorylation, serine/threonine protein kinase, transferase |
Biological source | HOMO SAPIENS (HUMAN) |
Cellular location | Cytoplasm (By similarity): Q16539 |
Total number of polymer chains | 1 |
Total formula weight | 41879.79 |
Authors | Tickle, J.,Cleasby, A.,Devine, L.A.,Jhoti, H. (deposition date: 2004-11-05, release date: 2005-11-03, Last modification date: 2011-07-13) |
Primary citation | Gill, A.L.,Frederickson, M.,Cleasby, A.,Woodhead, S.J.,Carr, M.G.,Woodhead, A.J.,Walker, M.T.,Congreve, M.S.,Devine, L.A.,Tisi, D.,O'Reilly, M.,Seavers, L.C.,Davis, D.J.,Curry, J.,Anthony, R.,Padova, A.,Murray, C.W.,Carr, R.A.,Jhoti, H. Identification of Novel P38Alpha Map Kinase Inhibitors Using Fragment-Based Lead Generation. J.Med.Chem., 48:414-, 2005 Cited by PubMed: 15658855DOI: 10.1021/JM049575N PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
Download full validation report