1WBS

Identification of novel p38 alpha MAP Kinase inhibitors using fragment-based lead generation.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	MITOGEN-ACTIVATED PROTEIN KINASE 14	polymer	360	41343.2	1	UniProt (Q16539) Pfam (PF00069) In PDB	HOMO SAPIENS (HUMAN)	MITOGEN-ACTIVATED PROTEIN KINASE P38ALPHA, MAP KINASE P38ALPHA, CYTOKINE SUPPRESSIVE ANTI-INFLAMMATORY DRUG BINDING PROTEIN, CSAID BINDING PROTEIN, CSBP, MAX-INTERACTING PROTEIN 2, MAP KINASE MXI2, SAPK2A
2	A	3-FLUORO-5-MORPHOLIN-4-YL-N-[3-(2-PYRIDIN-4-YLETHYL)-1H-INDOL-5-YL]BENZAMIDE	non-polymer		444.5	1	Chemie (LI2)
3	A	GLYCEROL	non-polymer		92.1	1	Chemie (GOL)
4		water	water		18.0	395	Chemie (HOH)

Sequence modifications

A: 1 - 1 (PDB: 1WBS)
A: 2 - 360 (UniProt: Q16539)

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	41343.2
Non-Polymers*	Number of molecules	2
	Total formula weight	536.6
All*	Total formula weight	41879.8

*Water molecules are not included.