1V1K

CDK2 IN COMPLEX WITH A DISUBSTITUTED 4, 6-BIS ANILINO PYRIMIDINE CDK4 INHIBITOR

Replaces:  1H06

Summary for 1V1K

• Entry DOI: 10.2210/pdb1v1k/pdb
• Related: 1AQ1 1B38 1B39 1BUH 1CKP 1DI8 1DM2 1E1V 1E1X 1E9H 1F5Q 1FIN 1FQ1 1FVT 1FVV 1G5S 1GIH 1GII 1GIJ 1GY3 1GZ8 1H00 1H01 1H07 1H08 1H0V 1H0W 1H1P 1H1Q 1H1R 1H1S 1H24 1H25 1H26 1H27 1H28 1HCK 1HCL 1JST 1JSU 1JSV 1JVP 1KE5 1KE6 1KE7 1KE8 1KE9 1OGU 1OI9 1OIQ 1OIR 1OIT 1OIU 1OIY 1OKU 1OKV 1OKW 1OL1 1OL2 1P2A 1P5E 1PF8 1PKD 1PW2 1PXI 1PXJ 1PXK 1PXL 1PXM 1PXN 1PXO 1PXP 1QMZ 1R78 1URC 1URW
• Descriptor: CELL DIVISION PROTEIN KINASE 2, (2R)-1-(DIMETHYLAMINO)-3-{4-[(6-{[2-FLUORO-5-(TRIFLUOROMETHYL)PHENYL]AMINO}PYRIMIDIN-4-YL)AMINO]PHENOXY}PROPAN-2-OL (3 entities in total)
• Functional Keywords: serine/threonine-protein kinase, mitosis, transferase
• Biological source: HOMO SAPIENS (HUMAN)
• Total number of polymer chains: 1
• Total formula weight: 34467.97

Authors

Beattie, J.F.,Breault, G.A.,Ellston, R.P.A.,Green, S.,Jewsbury, P.J.,Midgley, C.J.,Naven, R.T.,Minshull, C.A.,Pauptit, R.A.,Tucker, J.A.,Pease, J.E. (deposition date: 2004-04-16, release date: 2004-05-04, Last modification date: 2024-11-06)

Primary citation

Beattie, J.F.,Breault, G.A.,Ellston, R.P.A.,Green, S.,Jewsbury, P.J.,Midgley, C.J.,Naven, R.T.,Minshull, C.A.,Pauptit, R.A.,Tucker, J.A.,Pease, J.E.
Cyclin-Dependent Kinase 4 Inhibitors as a Treatment for Cancer. Part 1: Identification and Optimisation of Substituted 4,6-Bis Anilino Pyrimidines
Bioorg.Med.Chem.Lett., 13:2955-, 2003

PubMed Abstract: Using a high-throughput screening campaign, we identified the 4,6-bis anilino pyrimidines as inhibitors of the cyclin-dependent kinase, CDK4. Herein we describe the further chemical modification and use of X-ray crystallography to develop potent and selective in vitro inhibitors of CDK4.

PubMed: 12941311
DOI: 10.1016/S0960-894X(03)00202-6

Experimental method

X-RAY DIFFRACTION (2.31 Å)