5K47
| CryoEM structure of the human Polycystin-2/PKD2 TRP channel | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Polycystin-2 | Authors: | Pike, A.C.W, Grieben, M, Shintre, C.A, Tessitore, A, Shrestha, L, Mukhopadhyay, S, Mahajan, P, Chalk, R, Burgess-Brown, N.A, Huiskonen, J.T, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Carpenter, E.P, Structural Genomics Consortium (SGC) | Deposit date: | 2016-05-20 | Release date: | 2016-08-24 | Last modified: | 2020-10-21 | Method: | ELECTRON MICROSCOPY (4.2 Å) | Cite: | Structure of the polycystic kidney disease TRP channel Polycystin-2 (PC2). Nat. Struct. Mol. Biol., 24, 2017
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5T4D
| Cryo-EM structure of Polycystic Kidney Disease protein 2 (PKD2), residues 198-703 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, hPKD:198-703, Polycystin-2 | Authors: | Shen, P.S, Yang, X, DeCaen, P.G, Liu, X, Bulkley, D, Clapham, D.E, Cao, E. | Deposit date: | 2016-08-29 | Release date: | 2016-11-02 | Last modified: | 2020-07-29 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | The Structure of the Polycystic Kidney Disease Channel PKD2 in Lipid Nanodiscs. Cell, 167, 2016
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5MKE
| cryoEM Structure of Polycystin-2 in complex with cations and lipids | Descriptor: | 1,2-DIPALMITOYL-SN-GLYCERO-3-PHOSPHATE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Wilkes, M, Madej, M.G, Ziegler, C. | Deposit date: | 2016-12-04 | Release date: | 2017-01-18 | Last modified: | 2020-07-29 | Method: | ELECTRON MICROSCOPY (4.3 Å) | Cite: | Molecular insights into lipid-assisted Ca(2+) regulation of the TRP channel Polycystin-2. Nat. Struct. Mol. Biol., 24, 2017
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5MKF
| cryoEM Structure of Polycystin-2 in complex with calcium and lipids | Descriptor: | 1,2-DIPALMITOYL-SN-GLYCERO-3-PHOSPHATE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Wilkes, M, Madej, M.G, Ziegler, C. | Deposit date: | 2016-12-04 | Release date: | 2017-01-18 | Last modified: | 2020-07-29 | Method: | ELECTRON MICROSCOPY (4.2 Å) | Cite: | Molecular insights into lipid-assisted Ca(2+) regulation of the TRP channel Polycystin-2. Nat. Struct. Mol. Biol., 24, 2017
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5W3S
| Cryo-electron microscopy structure of a TRPML3 ion channel | Descriptor: | 1,2-Distearoyl-sn-glycerophosphoethanolamine, CHOLESTEROL HEMISUCCINATE, Mucolipin-3 isoform 1, ... | Authors: | Hirschi, M, Herzik, M.A, Wie, J, Suo, Y, Borschel, W.F, Ren, D, Lander, G.C, Lee, S.Y. | Deposit date: | 2017-06-08 | Release date: | 2017-10-11 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (2.94 Å) | Cite: | Cryo-electron microscopy structure of the lysosomal calcium-permeable channel TRPML3. Nature, 550, 2017
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5WJ9
| Human TRPML1 channel structure in agonist-bound open conformation | Descriptor: | 2-{2-oxo-2-[(4S)-2,2,4-trimethyl-3,4-dihydroquinolin-1(2H)-yl]ethyl}-1H-isoindole-1,3(2H)-dione, Mucolipin-1 | Authors: | Schmiege, P, Li, X. | Deposit date: | 2017-07-21 | Release date: | 2017-10-18 | Last modified: | 2019-12-18 | Method: | ELECTRON MICROSCOPY (3.49 Å) | Cite: | Human TRPML1 channel structures in open and closed conformations. Nature, 550, 2017
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5WJ5
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5WPT
| Cryo-EM structure of mammalian endolysosomal TRPML1 channel in nanodiscs in closed II conformation at 3.75 Angstrom resolution | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Mucolipin-1, SODIUM ION | Authors: | Chen, Q, She, J, Guo, J, Bai, X, Jiang, Y. | Deposit date: | 2017-08-07 | Release date: | 2017-10-18 | Last modified: | 2023-04-05 | Method: | ELECTRON MICROSCOPY (3.75 Å) | Cite: | Structure of mammalian endolysosomal TRPML1 channel in nanodiscs. Nature, 550, 2017
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5WPV
| Cryo-EM structure of mammalian endolysosomal TRPML1 channel in nanodiscs at 3.59 Angstrom resolution | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Mucolipin-1, SODIUM ION | Authors: | Chen, Q, She, J, Guo, J, Bai, X, Jiang, Y. | Deposit date: | 2017-08-07 | Release date: | 2017-10-18 | Last modified: | 2023-04-05 | Method: | ELECTRON MICROSCOPY (3.59 Å) | Cite: | Structure of mammalian endolysosomal TRPML1 channel in nanodiscs. Nature, 550, 2017
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5WPQ
| Cryo-EM structure of mammalian endolysosomal TRPML1 channel in nanodiscs in closed I conformation at 3.64 Angstrom resolution | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Mucolipin-1, SODIUM ION | Authors: | Chen, Q, She, J, Guo, J, Bai, X, Jiang, Y. | Deposit date: | 2017-08-07 | Release date: | 2017-10-18 | Last modified: | 2023-04-05 | Method: | ELECTRON MICROSCOPY (3.64 Å) | Cite: | Structure of mammalian endolysosomal TRPML1 channel in nanodiscs. Nature, 550, 2017
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6AYF
| TRPML3/ML-SA1 complex at pH 7.4 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Mucolipin-3 | Authors: | Zhou, X, Li, M, Su, D, Jia, Q, Li, H, Li, X, Yang, J. | Deposit date: | 2017-09-08 | Release date: | 2017-11-08 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (3.62 Å) | Cite: | Cryo-EM structures of the human endolysosomal TRPML3 channel in three distinct states. Nat. Struct. Mol. Biol., 24, 2017
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6AYG
| Human Apo-TRPML3 channel at pH 4.8 | Descriptor: | Mucolipin-3 | Authors: | Zhou, X, Li, M, Su, D, Jia, Q, Li, H, Li, X, Yang, J. | Deposit date: | 2017-09-08 | Release date: | 2017-11-08 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (4.65 Å) | Cite: | Cryo-EM structures of the human endolysosomal TRPML3 channel in three distinct states. Nat. Struct. Mol. Biol., 24, 2017
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6AYE
| Human apo-TRPML3 channel at pH 7.4 | Descriptor: | Mucolipin-3 | Authors: | Zhou, X, Li, M, Su, D, Jia, Q, Li, H, Li, X, Yang, J. | Deposit date: | 2017-09-08 | Release date: | 2017-11-08 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (4.06 Å) | Cite: | Cryo-EM structures of the human endolysosomal TRPML3 channel in three distinct states. Nat. Struct. Mol. Biol., 24, 2017
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5YE2
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5YE1
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5YE5
| structure of endo-lysosomal TRPML1 channel inserting into nanodisc | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, mammalian endo-lysosomal TRPML1 channel | Authors: | Yang, M, Gao, N. | Deposit date: | 2017-09-15 | Release date: | 2017-11-15 | Last modified: | 2020-07-29 | Method: | ELECTRON MICROSCOPY (5.8 Å) | Cite: | Cryo-EM structures of the mammalian endo-lysosomal TRPML1 channel elucidate the combined regulation mechanism Protein Cell, 8, 2017
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5YDZ
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5Z1W
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6D1W
| human PKD2 F604P mutant | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Polycystin-2 | Authors: | Zheng, W, Yang, X, Bulkley, D, Chen, X.Z, Cao, E. | Deposit date: | 2018-04-12 | Release date: | 2018-06-27 | Last modified: | 2020-07-29 | Method: | ELECTRON MICROSCOPY (3.54 Å) | Cite: | Hydrophobic pore gates regulate ion permeation in polycystic kidney disease 2 and 2L1 channels. Nat Commun, 9, 2018
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6DU8
| Human Polycsytin 2-l1 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Polycystic kidney disease 2-like 1 protein | Authors: | Hulse, R.E, Clapham, D.E, Li, Z, Huang, R.K, Zhang, J. | Deposit date: | 2018-06-20 | Release date: | 2018-07-25 | Last modified: | 2020-07-29 | Method: | ELECTRON MICROSCOPY (3.11 Å) | Cite: | Cryo-EM structure of the polycystin 2-l1 ion channel. Elife, 7, 2018
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6A70
| Structure of the human PKD1/PKD2 complex | Descriptor: | Polycystin-1, Polycystin-2 | Authors: | Su, Q, Hu, F, Ge, X, Lei, J, Yu, S, Wang, T, Zhou, Q, Mei, C, Shi, Y. | Deposit date: | 2018-06-29 | Release date: | 2018-08-15 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Structure of the human PKD1-PKD2 complex. Science, 361, 2018
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6E7P
| cryo-EM structure of human TRPML1 with PI35P2 | Descriptor: | (1R,2S,3S,4R,5S,6R)-5-{[(R)-[(2R)-2,3-bis{[(1S)-1-hydroxyoctyl]oxy}propoxy](hydroxy)phosphoryl]oxy}-2,4,6-trihydroxycyclohexane-1,3-diyl bis[dihydrogen (phosphate)], Mucolipin-1 | Authors: | Schmiege, P, Li, X. | Deposit date: | 2018-07-27 | Release date: | 2018-11-28 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Structural basis for PtdInsP2-mediated human TRPML1 regulation. Nat Commun, 9, 2018
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6E7Y
| cryo-EM structure of human TRPML1 with PI45P2 | Descriptor: | Mucolipin-1, [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate | Authors: | Schmiege, P, Li, X. | Deposit date: | 2018-07-27 | Release date: | 2018-11-28 | Method: | ELECTRON MICROSCOPY (3.57 Å) | Cite: | Structural basis for PtdInsP2-mediated human TRPML1 regulation. Nat Commun, 9, 2018
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6E7Z
| cryo-EM structure of human TRPML1 with ML-SA1 and PI35P2 | Descriptor: | (1R,2S,3S,4R,5S,6R)-5-{[(R)-[(2R)-2,3-bis{[(1S)-1-hydroxyoctyl]oxy}propoxy](hydroxy)phosphoryl]oxy}-2,4,6-trihydroxycyclohexane-1,3-diyl bis[dihydrogen (phosphate)], 2-{2-oxo-2-[(4S)-2,2,4-trimethyl-3,4-dihydroquinolin-1(2H)-yl]ethyl}-1H-isoindole-1,3(2H)-dione, Mucolipin-1 | Authors: | Schmiege, P, Li, X. | Deposit date: | 2018-07-27 | Release date: | 2018-11-28 | Method: | ELECTRON MICROSCOPY (3.73 Å) | Cite: | Structural basis for PtdInsP2-mediated human TRPML1 regulation. Nat Commun, 9, 2018
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6T9N
| CryoEM structure of human polycystin-2/PKD2 in UDM supplemented with PI(4,5)P2 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | Authors: | Wang, Q, Pike, A.C.W, Grieben, M, Baronina, A, Nasrallah, C, Shintre, C, Edwards, A.M, Arrowsmith, C.H, Bountra, C, Carpenter, E.P, Structural Genomics Consortium (SGC) | Deposit date: | 2019-10-28 | Release date: | 2019-11-20 | Last modified: | 2020-07-29 | Method: | ELECTRON MICROSCOPY (2.96 Å) | Cite: | Lipid Interactions of a Ciliary Membrane TRP Channel: Simulation and Structural Studies of Polycystin-2. Structure, 28, 2020
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