5WJ9
Human TRPML1 channel structure in agonist-bound open conformation
Summary for 5WJ9
Entry DOI | 10.2210/pdb5wj9/pdb |
EMDB information | 8840 8841 |
Descriptor | Mucolipin-1, 2-{2-oxo-2-[(4S)-2,2,4-trimethyl-3,4-dihydroquinolin-1(2H)-yl]ethyl}-1H-isoindole-1,3(2H)-dione (2 entities in total) |
Functional Keywords | human trpml1, membrane protein |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 4 |
Total formula weight | 261789.67 |
Authors | Schmiege, P.,Li, X. (deposition date: 2017-07-21, release date: 2017-10-18, Last modification date: 2019-12-18) |
Primary citation | Schmiege, P.,Fine, M.,Blobel, G.,Li, X. Human TRPML1 channel structures in open and closed conformations. Nature, 550:366-370, 2017 Cited by PubMed: 29019983DOI: 10.1038/nature24036 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.49 Å) |
Structure validation
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