5WJ9

Human TRPML1 channel structure in agonist-bound open conformation

Summary for 5WJ9

Entry DOI	10.2210/pdb5wj9/pdb
EMDB information	8840 8841
Descriptor	Mucolipin-1, 2-{2-oxo-2-[(4S)-2,2,4-trimethyl-3,4-dihydroquinolin-1(2H)-yl]ethyl}-1H-isoindole-1,3(2H)-dione (2 entities in total)
Functional Keywords	human trpml1, membrane protein
Biological source	Homo sapiens (Human)
Total number of polymer chains	4
Total formula weight	261789.67
Authors	Schmiege, P.,Li, X. (deposition date: 2017-07-21, release date: 2017-10-18, Last modification date: 2019-12-18)
Primary citation	Schmiege, P.,Fine, M.,Blobel, G.,Li, X. Human TRPML1 channel structures in open and closed conformations. Nature, 550:366-370, 2017 Cited by PubMed: 29019983 DOI: 10.1038/nature24036 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.49 Å)

Structure validation